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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL1087908
Molecular formula	C26H23FN4O2
IUPAC name	[(2S)-4-(3-fluoro-4-pyridin-4-ylbenzoyl)-2-methylpiperazin-1-yl]-(1H-indol-6-yl)methanone
Molecular weight	442.494
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.5
Synonyms	(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(3-fluoro-4-(pyridin-4-yl)phenyl)methanone BDBM50312799 1H-Indole-6-yl[(2S)-2beta-methyl-4-[3-fluoro-4-(4-pyridinyl)benzoyl]-1-piperazinyl] ketone
Inchi Key	XOLPBWFHVUUEEH-KRWDZBQOSA-N
Inchi ID	InChI=1S/C26H23FN4O2/c1-17-16-30(12-13-31(17)26(33)21-3-2-19-8-11-29-24(19)15-21)25(32)20-4-5-22(23(27)14-20)18-6-9-28-10-7-18/h2-11,14-15,17,29H,12-13,16H2,1H3/t17-/m0/s1
PubChem CID	46865987
ChEMBL	CHEMBL1087908
IUPHAR	N/A
BindingDB	50312799
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	-16.0 %	PMID20137933	ChEMBL
Activity	10.3 %	PMID20137933	ChEMBL

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