Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only
Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

You can:

GPCR

NameRelaxin-3 receptor 1
SpeciesHomo sapiens (Human)
GeneRXFP3
SynonymGPCR135
RXFPR3
RXFP3
RLN3R1
RLN3 receptor 1
[ Show all ]
DiseaseN/A
Length469
Amino acid sequenceMQMADAATIATMNKAAGGDKLAELFSLVPDLLEAANTSGNASLQLPDLWWELGLELPDGAPPGHPPGSGGAESADTEARVRILISVVYWVVCALGLAGNLLVLYLMKSMQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKAMCKIVSMVTSMNMYASVFFLTAMSVTRYHSVASALKSHRTRGHGRGDCCGRSLGDSCCFSAKALCVWIWALAALASLPSAIFSTTVKVMGEELCLVRFPDKLLGRDRQFWLGLYHSQKVLLGFVLPLGIIILCYLLLVRFIADRRAAGTKGGAAVAGGRPTGASARRLSKVTKSVTIVVLSFFLCWLPNQALTTWSILIKFNAVPFSQEYFLCQVYAFPVSVCLAHSNSCLNPVLYCLVRREFRKALKSLLWRIASPSITSMRPFTATTKPEHEDQGLQAPAPPHAAAEPDLLYYPPGVVVYSGGRYDLLPSSSAY
UniProtQ9NSD7
Protein Data BankN/A
GPCR-HGmod modelQ9NSD7
3D structure modelThis predicted structure model is from GPCR-EXP Q9NSD7.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1628472
IUPHAR353
DrugBankN/A

Ligand

NameCID 70694195
Molecular formulaC136H213N43O35
IUPAC name(4S)-4-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]propanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]amino]-5-[[(2S)-1-[[(2S,3S)-1-[[(2S)-5-carbamimidamido-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[2-[[2-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-5-oxopentanoic acid
Molecular weight3010.47
Hydrogen bond acceptor41
Hydrogen bond donor49
XlogP-7.3
SynonymsN/A
Inchi KeyXOVXGEANVVAAJE-LAGNKGSJSA-N
Inchi IDInChI=1S/C136H213N43O35/c1-15-71(9)106(127(209)166-86(39-27-51-150-134(142)143)115(197)159-74(12)110(192)175-105(70(7)8)126(208)177-107(72(10)16-2)128(210)170-93(57-78-33-21-18-22-34-78)122(204)178-108(76(14)183)129(211)173-96(66-181)114(196)155-61-99(185)154-62-100(186)162-97(67-182)123(205)163-87(40-28-52-151-135(144)145)118(200)171-94(131(213)214)59-80-60-153-84-37-24-23-35-82(80)84)176-121(203)92(56-77-31-19-17-20-32-77)168-119(201)89(47-48-103(189)190)164-116(198)85(38-26-50-149-133(140)141)161-101(187)63-157-113(195)95(65-180)172-120(202)90(55-68(3)4)167-117(199)88(41-29-53-152-136(146)147)165-125(207)104(69(5)6)174-102(188)64-156-112(194)91(58-79-43-45-81(184)46-44-79)169-124(206)98-42-30-54-179(98)130(212)75(13)160-109(191)73(11)158-111(193)83(137)36-25-49-148-132(138)139/h17-24,31-35,37,43-46,60,68-76,83,85-98,104-108,153,180-184H,15-16,25-30,36,38-42,47-59,61-67,137H2,1-14H3,(H,154,185)(H,155,196)(H,156,194)(H,157,195)(H,158,193)(H,159,197)(H,160,191)(H,161,187)(H,162,186)(H,163,205)(H,164,198)(H,165,207)(H,166,209)(H,167,199)(H,168,201)(H,169,206)(H,170,210)(H,171,200)(H,172,202)(H,173,211)(H,174,188)(H,175,192)(H,176,203)(H,177,208)(H,178,204)(H,189,190)(H,213,214)(H4,138,139,148)(H4,140,141,149)(H4,142,143,150)(H4,144,145,151)(H4,146,147,152)/t71-,72-,73-,74-,75-,76+,83-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,104-,105-,106-,107-,108-/m0/s1
PubChem CID70694195
ChEMBLCHEMBL2030691
IUPHARN/A
BindingDB50382994
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki2951.21 nMPMID22257012BindingDB,ChEMBL

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218