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GPCR

Name5-hydroxytryptamine receptor 1B
SpeciesRattus norvegicus (Rat)
GeneHtr1b
SynonymHTR1D2
5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
5-HT1Dbeta
5-HT1DB
5-HT1B serotonin receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length386
Amino acid sequenceMEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
UniProtP28564
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3459
IUPHAR2
DrugBankN/A

Ligand

Nameoxprenolol
Molecular formulaC15H23NO3
IUPAC name1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol
Molecular weight265.353
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.1
SynonymsPrestwick1_001057
1-(2-Allyloxy-phenoxy)-3-isopropylamino-propan-2-ol
Slow-Trasicor (TN)
1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)propan-2-ol
Trasicor (*hydrochloride*)
[ Show all ]
Inchi KeyCEMAWMOMDPGJMB-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H23NO3/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3/h4-8,12-13,16-17H,1,9-11H2,2-3H3
PubChem CID4631
ChEMBLCHEMBL546
IUPHARN/A
BindingDB50240370
DrugBankDB01580

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki173.78 nMPMID1968985BindingDB

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