You can:
Name | Free fatty acid receptor 1 |
---|---|
Species | Homo sapiens (Human) |
Gene | FFAR1 |
Synonym | FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 FFA1 receptor |
Disease | Type 2 diabetes Non-insulin dependent diabetes Diabetes |
Length | 300 |
Amino acid sequence | MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK |
UniProt | O14842 |
Protein Data Bank | 5tzy, 5tzr |
GPCR-HGmod model | O14842 |
3D structure model | This structure is from PDB ID 5tzy. |
BioLiP | BL0380462, BL0380463, BL0380464 |
Therapeutic Target Database | T25608 |
ChEMBL | CHEMBL4422 |
IUPHAR | 225 |
DrugBank | BE0000688 |
Name | CHEMBL1777861 |
---|---|
Molecular formula | C20H15F5O4 |
IUPAC name | 3-[4-[2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy]phenyl]hex-4-ynoic acid |
Molecular weight | 414.328 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 1 |
XlogP | 5.6 |
Synonyms | BDBM50344068 rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)hex-4-ynoic acid |
Inchi Key | XTXMTBWPTJUGRV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H15F5O4/c1-2-3-13(10-18(26)27)12-4-7-15(8-5-12)28-16-9-6-14(20(23,24)25)11-17(16)29-19(21)22/h4-9,11,13,19H,10H2,1H3,(H,26,27) |
PubChem CID | 53248846 |
ChEMBL | CHEMBL1777861 |
IUPHAR | N/A |
BindingDB | 50344068 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 71.0 nM | PMID21514824 | BindingDB,ChEMBL |
EC50 | 436.0 nM | PMID21514824 | BindingDB,ChEMBL |
EC50 | 455.0 nM | PMID21514824 | BindingDB,ChEMBL |
IC50 | 12.0 nM | PMID21514824 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218