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Name | Free fatty acid receptor 1 |
---|---|
Species | Mus musculus (Mouse) |
Gene | Ffar1 |
Synonym | FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 |
Disease | N/A for non-human GPCRs |
Length | 300 |
Amino acid sequence | MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK |
UniProt | Q76JU9 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5411 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL1777861 |
---|---|
Molecular formula | C20H15F5O4 |
IUPAC name | 3-[4-[2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy]phenyl]hex-4-ynoic acid |
Molecular weight | 414.328 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 1 |
XlogP | 5.6 |
Synonyms | BDBM50344068 rac-3-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)hex-4-ynoic acid |
Inchi Key | XTXMTBWPTJUGRV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H15F5O4/c1-2-3-13(10-18(26)27)12-4-7-15(8-5-12)28-16-9-6-14(20(23,24)25)11-17(16)29-19(21)22/h4-9,11,13,19H,10H2,1H3,(H,26,27) |
PubChem CID | 53248846 |
ChEMBL | CHEMBL1777861 |
IUPHAR | N/A |
BindingDB | 50344068 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 77.0 nM | PMID21514824 | BindingDB,ChEMBL |
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