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Name | Muscarinic acetylcholine receptor M2 |
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Species | Homo sapiens (Human) |
Gene | CHRM2 |
Synonym | cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 [ Show all ] |
Disease | Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer [ Show all ] |
Length | 466 |
Amino acid sequence | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P08172 |
Protein Data Bank | 5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8 |
GPCR-HGmod model | P08172 |
3D structure model | This structure is from PDB ID 5zkc. |
BioLiP | BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338 |
Therapeutic Target Database | T46185 |
ChEMBL | CHEMBL211 |
IUPHAR | 14 |
DrugBank | BE0000560 |
Name | CHEMBL109051 |
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Molecular formula | C35H37FN2O4S |
IUPAC name | (4-fluoronaphthalen-1-yl)-[4-[4-[[4-(4-methoxyphenyl)sulfonylphenyl]methyl]piperidin-1-yl]piperidin-1-yl]methanone |
Molecular weight | 600.749 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 6.8 |
Synonyms | BDBM50104942 (4-Fluoro-naphthalen-1-yl)-{4-[4-(4-methoxy-benzenesulfonyl)-benzyl]-[1,4'']bipiperidinyl-1''-yl}-methanone |
Inchi Key | XVOCHVRQMXWEQB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H37FN2O4S/c1-42-28-8-12-30(13-9-28)43(40,41)29-10-6-25(7-11-29)24-26-16-20-37(21-17-26)27-18-22-38(23-19-27)35(39)33-14-15-34(36)32-5-3-2-4-31(32)33/h2-15,26-27H,16-24H2,1H3 |
PubChem CID | 44337326 |
ChEMBL | CHEMBL109051 |
IUPHAR | N/A |
BindingDB | 50104942 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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Ki | 1.3 nM | PMID12086500 | BindingDB,ChEMBL |
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