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GPCR

NameAlpha-2C adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2C
Synonymalpha2-C4
Adra-2c
ADRA2L2
ADRA2RL2
Adrenergic alpha2C- receptor class I
[ Show all ]
DiseaseDiabetic nephropathy; Fibromyalgia
Hypertension
Heart failure
Glaucoma
Alzheimer disease
[ Show all ]
Length462
Amino acid sequenceMASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP18825
Protein Data BankN/A
GPCR-HGmod modelP18825
3D structure modelThis predicted structure model is from GPCR-EXP P18825.
BioLiPN/A
Therapeutic Target DatabaseT01777
ChEMBLCHEMBL1916
IUPHAR27
DrugBankBE0004864, BE0000342, BE0004888

Ligand

Namebrimonidine
Molecular formulaC11H10BrN5
IUPAC name5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
Molecular weight292.14
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP0.6
SynonymsDB00484
FT-0082636
5-brom-n-(4,5-dihydro-1h-imidazol-2-yl)chinoxalin-6-amin
HMS3266O03
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine
[ Show all ]
Inchi KeyXYLJNLCSTIOKRM-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
PubChem CID2435
ChEMBLCHEMBL844
IUPHAR520
BindingDB34572
DrugBankDB00484

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
EC503.4 nMPMID9016324BindingDB,ChEMBL
EC508.0 nMNoneChEMBL
EC509.5 nMN/ABindingDB
EC509.55 nMBioorg. Med. Chem. Lett., (1995) 5:19:2255ChEMBL
Emax93.0 %NoneChEMBL
IA0.82 -PMID9016324ChEMBL
Intrinsic activity1.0 -Bioorg. Med. Chem. Lett., (1995) 5:19:2255ChEMBL
Ki25.1189 - 1995.26 nMPMID9824686, PMID9605427, PMID9760042, PMID9227000IUPHAR
Ki44.0 nMPMID9016324BindingDB,ChEMBL
Ki83.0 nMN/ABindingDB
Ki83.18 nMBioorg. Med. Chem. Lett., (1995) 5:19:2255ChEMBL
Ki1949.84 nMPMID9605427BindingDB
Ki1949.84 nMPMID9605427PDSP

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