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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 52
Species	Homo sapiens (Human)
Gene	GPR52
Synonym	GPR52
Disease	N/A
Length	361
Amino acid sequence	MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
UniProt	Q9Y2T5
Protein Data Bank	N/A
GPCR-HGmod model	Q9Y2T5
3D structure model	This predicted structure model is from GPCR-EXP Q9Y2T5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3297639
IUPHAR	108
DrugBank	N/A

Ligand

Name	CHEMBL3297810
Molecular formula	C25H19F3N2O2S
IUPAC name	N-(2-amino-2-oxoethyl)-3-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]benzamide
Molecular weight	468.494
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.6
Synonyms	J3.566.757A SCHEMBL1852605 N-(2-Amino-2-oxoethyl)-3-[2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl]benzamide YEXFTFGLKGVAPD-UHFFFAOYSA-N N-(2-Oxo-2-aminoethyl)-3-[2-[3-(trifluoromethyl)benzyl]benzo[b]thiophene-7-yl]benzamide BDBM50022170 [ Show all ]
Inchi Key	YEXFTFGLKGVAPD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H19F3N2O2S/c26-25(27,28)19-8-1-4-15(10-19)11-20-13-17-6-3-9-21(23(17)33-20)16-5-2-7-18(12-16)24(32)30-14-22(29)31/h1-10,12-13H,11,14H2,(H2,29,31)(H,30,32)
PubChem CID	59193981
ChEMBL	CHEMBL3297810
IUPHAR	N/A
BindingDB	50022170
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	54.95 nM	PMID24884590	ChEMBL
EC50	55.0 nM	PMID24884590	BindingDB
Emax	102.0 %	PMID24884590	ChEMBL

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