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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Rattus norvegicus (Rat)
Gene	Htr7
Synonym	GPRFO 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 5-HTx 5-HT7 receptor 5-HT7 5-HT1Y 5-HT-X 5-HT-7 Serotonin receptor 7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	448
Amino acid sequence	MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
UniProt	P32305
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3223
IUPHAR	12
DrugBank	N/A

Ligand

Name	CHEMBL240729
Molecular formula	C48H66N4O4
IUPAC name	1-(2-methoxyphenyl)-4-[2-[3-[10-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]phenoxy]decoxy]phenyl]ethyl]piperazine
Molecular weight	763.08
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	10.9
Synonyms	BDBM50213541 1,10-bis-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]phenoxy]decane
Inchi Key	CFWSAXZHOITROD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C48H66N4O4/c1-53-47-23-11-9-21-45(47)51-33-29-49(30-34-51)27-25-41-17-15-19-43(39-41)55-37-13-7-5-3-4-6-8-14-38-56-44-20-16-18-42(40-44)26-28-50-31-35-52(36-32-50)46-22-10-12-24-48(46)54-2/h9-12,15-24,39-40H,3-8,13-14,25-38H2,1-2H3
PubChem CID	44437332
ChEMBL	CHEMBL240729
IUPHAR	N/A
BindingDB	50213541
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	28.3 nM	PMID17517509	BindingDB,ChEMBL
Ki	258.0 nM	PMID17517509	BindingDB,ChEMBL

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