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Name | Prostacyclin receptor |
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Species | Homo sapiens (Human) |
Gene | PTGIR |
Synonym | prostanoid IP receptor prostaglandin I2 receptor prostaglandin I2 (prostacyclin) receptor (IP) prostacyclin receptor PGI2 receptor [ Show all ] |
Disease | Solid tumours Pulmonary hypertension Medical abortion Pulmonary arterial hypertension Hypertension [ Show all ] |
Length | 386 |
Amino acid sequence | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC |
UniProt | P43119 |
Protein Data Bank | N/A |
GPCR-HGmod model | P43119 |
3D structure model | This predicted structure model is from GPCR-EXP P43119. |
BioLiP | N/A |
Therapeutic Target Database | T99954 |
ChEMBL | CHEMBL1995 |
IUPHAR | 345 |
DrugBank | BE0000475 |
Name | CHEMBL9541 |
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Molecular formula | C16H15N3O2S |
IUPAC name | 4-[4-(4,5-dihydro-1H-imidazol-2-ylamino)phenyl]sulfanylbenzoic acid |
Molecular weight | 313.375 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 2.7 |
Synonyms | DTXSID00465231 BDBM50223836 SCHEMBL5806616 Benzoic acid, 4-[[4-[(4,5-dihydro-1H-imidazol-2-yl)amino]phenyl]thio]- CTK1J2992 [ Show all ] |
Inchi Key | CGEBRDJCQDVYMW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H15N3O2S/c20-15(21)11-1-5-13(6-2-11)22-14-7-3-12(4-8-14)19-16-17-9-10-18-16/h1-8H,9-10H2,(H,20,21)(H2,17,18,19) |
PubChem CID | 11415742 |
ChEMBL | CHEMBL9541 |
IUPHAR | N/A |
BindingDB | 50223836 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | >10000.0 nM | PMID15013022 | BindingDB,ChEMBL |
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