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GPCR

NameMelanocortin receptor 3
SpeciesHomo sapiens (Human)
GeneMC3R
SynonymMC3-R
melanocortin receptor 3
MC3 receptor
gamma-MSH receptor
DiseaseSexual dysfunction; Obesity; Type 2 diabetes
Length323
Amino acid sequenceMNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG
UniProtP41968
Protein Data BankN/A
GPCR-HGmod modelP41968
3D structure modelThis predicted structure model is from GPCR-EXP P41968.
BioLiPN/A
Therapeutic Target DatabaseT76846
ChEMBLCHEMBL4644
IUPHAR284
DrugBankN/A

Ligand

NameCHEMBL393359
Molecular formulaC27H31N3O
IUPAC nameN-(5-aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
Molecular weight413.565
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP4.6
SynonymsBDBM50217651
N-(5-aminopentyl)-3-(1H-indol-3-yl)-N-(naphthalen-2-ylmethyl)propanamide
Inchi KeyCGIXVWNBAIUFQT-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H31N3O/c28-16-6-1-7-17-30(20-21-12-13-22-8-2-3-9-23(22)18-21)27(31)15-14-24-19-29-26-11-5-4-10-25(24)26/h2-5,8-13,18-19,29H,1,6-7,14-17,20,28H2
PubChem CID10158674
ChEMBLCHEMBL393359
IUPHARN/A
BindingDB50217651
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki58000.0 nMPMID17618123BindingDB,ChEMBL

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