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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

NameMLS000117714
Molecular formulaC19H26N2O5S
IUPAC name2-[[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfonyl]-N-(3-methylbutyl)acetamide
Molecular weight394.486
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP2.6
SynonymsMLS002587356
BDBM37786
cid_5307092
SCHEMBL12008022
2-[[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfonyl]-N-(3-methylbutyl)ethanamide
[ Show all ]
Inchi KeyCGNPCWDCNXIDCJ-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H26N2O5S/c1-13(2)8-9-20-18(22)12-27(23,24)11-17-14(3)26-19(21-17)15-6-5-7-16(10-15)25-4/h5-7,10,13H,8-9,11-12H2,1-4H3,(H,20,22)
PubChem CID5307092
ChEMBLCHEMBL1545295
IUPHARN/A
BindingDB37786
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<43700.0 nMN/ABindingDB
Ki<66700.0 nMPubChem BioAssay data setChEMBL

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