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GPCR

NameProstaglandin D2 receptor 2
SpeciesMus musculus (Mouse)
GenePtgdr2
SynonymPGD2 receptor
Gpr44
G-protein coupled receptor 44
G protein-coupled receptor 44
DP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length382
Amino acid sequenceMANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProtQ9Z2J6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2291
IUPHAR339
DrugBankN/A

Ligand

NameNVP-QAV680
Molecular formulaC18H18N2O4S
IUPAC name2-[2-methyl-1-[(4-methylsulfonylphenyl)methyl]pyrrolo[2,3-b]pyridin-3-yl]acetic acid
Molecular weight358.412
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP2.0
Synonyms2-(2-methyl-1-(4-(methylsulfonyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid
CHEMBL2442750
QAV-680
872365-16-7
GTPL8996
[ Show all ]
Inchi KeyYOPFAMROKXHVCQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H18N2O4S/c1-12-16(10-17(21)22)15-4-3-9-19-18(15)20(12)11-13-5-7-14(8-6-13)25(2,23)24/h3-9H,10-11H2,1-2H3,(H,21,22)
PubChem CID11508736
ChEMBLCHEMBL2442750
IUPHARN/A
BindingDB50442299
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5094.0 nMPMID24021582BindingDB,ChEMBL
Ki10.0 nMPMID24021582BindingDB,ChEMBL

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