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GPCR

NameProstaglandin F2-alpha receptor
SpeciesBos taurus (Bovine)
GenePTGFR
SynonymPGF receptor
PGF2-alpha receptor
Prostanoid FP receptor
DiseaseN/A for non-human GPCRs
Length362
Amino acid sequenceMSTNSSIQPVSPESELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQKYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYKTDEIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKDSLKVAAISDLPVTEKVTQQTST
UniProtP37289
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4820
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL185559
Molecular formulaC23H29F3O6
IUPAC name(Z)-8-[(2R,3S,4R)-4-hydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]oxolan-3-yl]oct-4-enoic acid
Molecular weight458.474
Hydrogen bond acceptor9
Hydrogen bond donor3
XlogP3.4
SynonymsBDBM50150892
(Z)-8-{(2R,3S,4R)-4-Hydroxy-2-[(E)-(R)-3-hydroxy-4-(3-trifluoromethyl-phenoxy)-but-1-enyl]-tetrahydro-furan-3-yl}-oct-4-enoic acid
Inchi KeyYSNMVDVQOSTSDX-YCDPIYLCSA-N
Inchi IDInChI=1S/C23H29F3O6/c24-23(25,26)16-7-6-8-18(13-16)31-14-17(27)11-12-21-19(20(28)15-32-21)9-4-2-1-3-5-10-22(29)30/h1,3,6-8,11-13,17,19-21,27-28H,2,4-5,9-10,14-15H2,(H,29,30)/b3-1-,12-11+/t17-,19+,20+,21-/m1/s1
PubChem CID44393431
ChEMBLCHEMBL185559
IUPHARN/A
BindingDB50150892
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki350.0 nMPMID15357985BindingDB,ChEMBL

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