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GPCR

NameVasopressin V2 receptor
SpeciesRattus norvegicus (Rat)
GeneAvpr2
SynonymAVPR V2
Antidiuretic hormone receptor
ADHR
Renal-type arginine vasopressin receptor
V2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length371
Amino acid sequenceMLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProtQ00788
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3766
IUPHAR368
DrugBankN/A

Ligand

NameCHEMBL2373510
Molecular formulaC60H89N17O11
IUPAC name(2S)-N-[(2S)-6-amino-1-[(2R)-2-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2R)-3-(4-ethoxyphenyl)-2-[(2-phenylacetyl)amino]propanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]butanediamide
Molecular weight1224.48
Hydrogen bond acceptor14
Hydrogen bond donor14
XlogP-0.7
SynonymsN/A
Inchi KeyCHODXWJGDHIOHT-JQJPBZKSSA-N
Inchi IDInChI=1S/C60H89N17O11/c1-4-88-40-26-24-39(25-27-40)33-44(70-49(79)34-38-18-9-6-10-19-38)53(82)74-45(32-37-16-7-5-8-17-37)55(84)76-50(36(2)3)57(86)75-46(35-48(62)78)54(83)73-43(20-11-12-28-61)58(87)77-31-15-23-47(77)56(85)72-42(22-14-30-69-60(66)67)52(81)71-41(51(63)80)21-13-29-68-59(64)65/h5-10,16-19,24-27,36,41-47,50H,4,11-15,20-23,28-35,61H2,1-3H3,(H2,62,78)(H2,63,80)(H,70,79)(H,71,81)(H,72,85)(H,73,83)(H,74,82)(H,75,86)(H,76,84)(H4,64,65,68)(H4,66,67,69)/t41-,42-,43-,44+,45-,46-,47+,50-/m0/s1
PubChem CID44335003
ChEMBLCHEMBL2373510
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Effective dose9.8 nM kg-1PMID2231609ChEMBL
Ratio41.0 -PMID2231609ChEMBL

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