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GPCR

NameAlpha-1D adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1d
SynonymADRA1A
Gpcr8
Adra-1
alpha1D-AR
alpha1D-adrenoceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length561
Amino acid sequenceMTFRDILSVTFEGPRSSSSTGGSGAGGGAGTVGPEGGAVGGVPGATGGGAVVGTGSGEDNQSSTGEPGAAASGEVNGSAAVGGLVVSAQGVGVGVFLAAFILTAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSAAVLPFSATMEVLGFWAFGRTFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWAVALVVSVGPLLGWKEPVPPDERFCGITEEVGYAIFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGIKREPGKASEVVLRIHCRGAATSAKGYPGTQSSKGHTLRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRLWAVYGHHWRASTGDARSDCAPSPRIAPPGAPLALTAHPGAGSADTPETQDSVSSSRKPASALREWRLLGPLQRPTTQLRAKVSSLSHKIRSGARRAETACALRSEVEAVSLNVPQDGAEAVICQAYEPGDYSNLRETDI
UniProtP23944
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL326
IUPHAR24
DrugBankN/A

Ligand

NameCHEMBL65846
Molecular formulaC18H16N2O3
IUPAC name5-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol
Molecular weight308.337
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP1.7
Synonyms5-(1,3-Benzodioxole-5-ylmethyl)-2,3-dihydro-5H-imidazo[2,1-a]isoindole-5-ol
3H-Imidazo[2,1-a]isoindol-5-ol, 5-(1,3-benzodioxol-5-ylmethyl)-2,5-dihydro-
5-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol
Inchi KeyAFMNHKBYDLREAC-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H16N2O3/c21-18(10-12-5-6-15-16(9-12)23-11-22-15)14-4-2-1-3-13(14)17-19-7-8-20(17)18/h1-6,9,21H,7-8,10-11H2
PubChem CID15959139
ChEMBLCHEMBL65846
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity47.0 %PMID16513345ChEMBL

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