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GPCR

NameP2Y purinoceptor 1
SpeciesRattus norvegicus (Rat)
GeneP2ry1
SynonymATP receptor
purinergic receptor P2Y
Purinergic receptor
platelet ADP receptor
P2Y1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length373
Amino acid sequenceMTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
UniProtP49651
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2497
IUPHARN/A
DrugBankN/A

Ligand

NameAdenosine triphosphate
Molecular formulaC10H16N5O13P3
IUPAC name[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight507.181
Hydrogen bond acceptor17
Hydrogen bond donor7
XlogP-5.7
SynonymsGlucobasin
AC1L1LHX
Phosphobion
Adenosine 5'-triphosphate (intravenous, arrhythmia), Duska
Triphosadenine (DCF)
[ Show all ]
Inchi KeyZKHQWZAMYRWXGA-KQYNXXCUSA-N
Inchi IDInChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
PubChem CID5957
ChEMBLCHEMBL14249
IUPHAR1713
BindingDB50366480, 2
DrugBankDB00171

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50200.0 nMPMID22873688BindingDB,ChEMBL
EC50590.0 nMPMID15317453BindingDB,ChEMBL

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