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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	64022-27-1
Molecular formula	C8H11ClN4
IUPAC name	2-chloro-6-piperazin-1-ylpyrazine
Molecular weight	198.654
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	0.5
Synonyms	6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl(MK-212) AC1Q3PR0 GTPL165 MK212 SCHEMBL255453 2-Chloro-6-(1-piperazinyl)pyrazine 61655-58-1 (mono-hydrochloride) Biomol-NT_000130 CTK8D5384 L001055 NSC-317326 ZINC1571800 AB21523 C90119 DTXSID80214007 MK 212 PDSP2_000725 1-(6-chloro-2-pyrazinyl)piperazine 6-Chloro-2-(1-piperazinyl)pyrazine AKOS006229696 CHEMBL269521 KB-199285 NCGC00024891-01 Tocris-0941 2-chloro-6-(piperazin-1-yl)pyrazine 62C3N7238U BPBio1_000111 D02ESW LS-127601 NSC317326 6''-Chloro-3,4,5,6-tetrahydro-2H-[1,2'']bipyrazinyl AC1L334H CHEBI:92360 FT-0707954 MK-212 Pyrazine, 2-chloro-6-(1-piperazinyl)- 6-chloro-2-[1-piperazinyl]-pyrazine BDBM50017452 CJAWPFJGFFNXQI-UHFFFAOYSA-N L-630,571 NCGC00024891-02 UNII-62C3N7238U 2-chloro-6-piperazin-1-ylpyrazine BRD-K19554809-001-01-1 DB12111 M-3644 PDSP1_000735 [ Show all ]
Inchi Key	CJAWPFJGFFNXQI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H11ClN4/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13/h5-6,10H,1-4H2
PubChem CID	107992
ChEMBL	CHEMBL269521
IUPHAR	165
BindingDB	50017452
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	150.0 nM	PMID9928251, PMID10611640	BindingDB
Ki	255.0 nM	PMID1347569	BindingDB
Ki	338.84 nM	PMID7984267	BindingDB
Ki	2552.0 nM	PMID9928251, PMID10611640	BindingDB

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