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Name | 5-hydroxytryptamine receptor 1D |
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Species | Sus scrofa (Pig) |
Gene | HTR1D |
Synonym | 5-HT-1D 5-HT1D Serotonin receptor 1D |
Disease | N/A for non-human GPCRs |
Length | 291 |
Amino acid sequence | AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV |
UniProt | P79400 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4105 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL50834 |
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Molecular formula | C16H22N6 |
IUPAC name | 2-[5-[(1-ethyltetrazol-5-yl)methyl]-1H-indol-3-yl]-N,N-dimethylethanamine |
Molecular weight | 298.394 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 2.2 |
Synonyms | BDBM50407351 N,N-Dimethyl-5-[(1-ethyl-1H-tetrazol-5-yl)methyl]-1H-indole-3-(ethanamine) SCHEMBL8784123 |
Inchi Key | CJBANWVQVZIEGT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H22N6/c1-4-22-16(18-19-20-22)10-12-5-6-15-14(9-12)13(11-17-15)7-8-21(2)3/h5-6,9,11,17H,4,7-8,10H2,1-3H3 |
PubChem CID | 10108730 |
ChEMBL | CHEMBL50834 |
IUPHAR | N/A |
BindingDB | 50407351 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 25.12 nM | PMID7752204 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218