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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesHomo sapiens (Human)
GeneHTR1A
Synonym5-HT-1A
5-HT1A
serotonin receptor 1A
5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
[ Show all ]
DiseaseUrinary incontinence
Generalized anxiety disorder
Generalized anxiety disorder; Social phobia
Hypertension
Hypoactive sexual desire disorder
[ Show all ]
Length422
Amino acid sequenceMDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
UniProtP08908
Protein Data BankN/A
GPCR-HGmod modelP08908
3D structure modelThis predicted structure model is from GPCR-EXP P08908.
BioLiPN/A
Therapeutic Target DatabaseT78709
ChEMBLCHEMBL214
IUPHAR1
DrugBankBE0000291

Ligand

Namechlorpromazine
Molecular formulaC17H19ClN2S
IUPAC name3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight318.863
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.2
SynonymsM-1209
Spectrum5_000717
NCGC00015273-02
Thorazine Spansule
NCGC00015273-10
[ Show all ]
Inchi KeyZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID2726
ChEMBLCHEMBL71
IUPHAR83
BindingDB50001888
DrugBankDB00477

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
Ki116.4 nMPMID12629531PDSP,BindingDB
Ki630.957 nMPMID9760039IUPHAR
Ki673.0 nMPMID8097537BindingDB
Ki673.0 nMPMID8097537, PMID8097538BindingDB,ChEMBL
Ki3000.0 nMPMID16051647PDSP
Ki3115.0 nMhttp://pdsp.med.unc.edu/pdsp.php, PMID9686407PDSP,BindingDB

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