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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Homo sapiens (Human)
Gene	HTR2C
Synonym	Serotonin receptor 2C serotonin 1c receptor 5-HT1C 5-HT2C 5-HT-2C 5-HT2C receptor 5-HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 1C HTR1C 5-HT-1C [ Show all ]
Disease	Pain Sleep initiation and maintenance disorders; Primary insomnia; Schizophrenia Unspecified Depression Drug abuse Generalized anxiety disorder; Major depressive disorder Major depressive disorder Metabolic disorders Psychotic disorders Mood disorder Neurological disease Obesity Obesity; Diabetes Migraine headaches Anxiety disorder Alcohol use disorders Aggressive non-hodgkin's lymphoma [ Show all ]
Length	458
Amino acid sequence	MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
UniProt	P28335
Protein Data Bank	6bqg, 6bqh
GPCR-HGmod model	P28335
3D structure model	This structure is from PDB ID 6bqg.
BioLiP	BL0404805, BL0404806
Therapeutic Target Database	T83813
ChEMBL	CHEMBL225
IUPHAR	8
DrugBank	BE0004957, BE0004881, BE0000533

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	AB00051943-16 Pharmakon1600-01500184 Fenaktyl Aminazin Prazilpromactil HMS2089C12 BAS 00010434 Promazil JHICC02042 Biomol-NT_000020 RP-4560 KBio2_007448 Largactil Oral Drops CAS-50-53-3 SMR001453710 KS-5101 M176 Chlor-PZ Spectrum_000142 (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00015273-03 Chlorpromazin Thorazine Suppositories 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine NCGC00015273-11 Chlorpromazinum Wintermin 2601-A NCGC00024409-04 Cromedazine [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) 4560 R.P Novomazina DSSTox_GSID_22808 EINECS 200-045-8 AB0015094 Phenothiazine hydrochloride GG 407 Amplicitil Prestwick2_000064 HMS501P06 BCP03610 Prozil KBio2_000622 BRD-K89997465-001-05-3 SC-50091 KBioGR_000806 Lomazine (Salt/Mix) CCRIS 3711 SPECTRUM1500184 MLS003166901 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine STK182870 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine NCGC00015273-06 Chlorpromazine cation radical Tox21_110120_1 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine NCGC00015273-14 Clorpromazina [INN-Spanish] ZINC44027 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # NCGC00024409-07 D01ZII 50-53-3 NSC-756689 AB00051943 NSC756689 Esmind ALBB-022464 Plegomasine HL 5746 API0001970 Promactil IDI1_000624 Bio1_000946 QTL1_000021 KBio2_004880 Largactil (TN) C06906 SKF 2601A KBioSS_002314 LS-105361 CHEMBL71 Spectrum4_000283 NCGC00015273-01 Chlorpromados Thorazine hydrochloride 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine NCGC00015273-09 Chlorpromazine [USP:INN:BAN] UNII-U42B7VYA4P 2-Cloro-10 (3-dimetilaminopropil)fenotiazina NCGC00015273-17 Contomin [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine Norcozine (Salt/Mix) DivK1c_000624 AB00051943_17 Phenactyl Fraction AB Aminazine Prestwick0_000064 HMS2091E06 BBL028251 Propaphen KB-232587 BPBio1_000273 Sanopron KBio3_001231 Largactilothiazine CAS-69-09-0 SPBio_001111 KSC-315-032- MCULE-5976054678 Chlordelazine SR-01000000012-5 (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00015273-04 Torazina 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine NCGC00015273-12 Chlorpromazinum [INN-Latin] WLN: T C666 BN ISJ B3N1&1 EG 2601A NCGC00024409-05 CTK1C5154 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) 4560 R.P. NSC 167745 DSSTox_RID_76736 Elmarin AC1L1EBT Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- GTPL83 Amplictil Prestwick3_000064 HSDB 3033 BDBM50001888 Psychozine KBio2_002312 L000182 BSPBio_000247 SCHEMBL8321 KBioGR_002312 Lopac-C-8138 CHEBI:3647 Spectrum2_001156 MolPort-001-727-953 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] Thorazine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- NCGC00015273-07 Chlorpromazine Tannate Tranzine (Salt/Mix) 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine NCGC00015273-15 Clorpromazina [Italian] ZPEIMTDSQAKGNT-UHFFFAOYSA-N 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine NCGC00024409-08 NSC167745 AB00051943-15 Oprea1_110255 Fenactil Aminasine Plegomazin HMS1920M03 AX8120990 Promapar J10069 Bio1_001435 R1242 KBio2_005758 Largactil Liquid C17H19ClN2S SKF-2601 KS-00002WW5 M-1209 Chlor-Promanyl Spectrum5_000717 NCGC00015273-02 Chlorpromanyl (discontinued) Thorazine Spansule 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine NCGC00015273-10 Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Unitensen 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] NCGC00015273-19 CPZ [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 34468-21-8 Novo-Chlorpromazine DSSTox_CID_2808 DTXSID0022808 AB00051943_18 Phenathyl FT-0653683 Ampliactil Prestwick1_000064 HMS3430C19 BC 135 Propaphenin KBio1_000624 BPBio1_001181 SBI-0050237.P004 KBio3_002792 Largactyl CCG-40059 SPBio_002168 KUC112482N Megaphen Chlorderazin SR-01000000012-6 NCGC00015273-05 Chlorpromazine (USP/INN) Tox21_110120 2-chloro-10-[3-(dimethylamino)propyl]- NCGC00015273-13 Clorpromazina Z80 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine NCGC00024409-06 D00270 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) 4560 Rp hydrochloride NSC-167745 NSC17479 Epitope ID:136898 AKOS001490972 Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Hibernal (Salt/Mix) AN-41563 Proma I14-6226 Bio1_000457 QSPL 401 KBio2_003190 Largactil BSPBio_002011 SKF 2601-A KBioSS_000622 Lopac0_000249 Spectrum3_000346 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Chloropromazine Thorazine (TN) 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) NCGC00015273-08 Chlorpromazine [USAN:INN:BAN] U42B7VYA4P 2-Chloropromazine NCGC00015273-16 cMAP_000017 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine NINDS_000624 DB00477 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	5.235 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	1.4 nM	PMID2904784	BindingDB
Ki	2.742 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	6.1 nM	PMID10991983	PDSP
Ki	6.30957 - 25.1189 nM	PMID12629531, PMID10991983	IUPHAR
Ki	25.0 nM	PMID12629531	PDSP,BindingDB
Ki	27.0 nM	PMID21907583	BindingDB,ChEMBL
Ki	30.0 nM	PMID24365159	ChEMBL
Ki	30.2 nM	PMID24365159	ChEMBL
Ki	39.81 nM	PMID17880057	ChEMBL

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