You can:
Name | 5-hydroxytryptamine receptor 6 |
---|---|
Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | chlorpromazine |
---|---|
Molecular formula | C17H19ClN2S |
IUPAC name | 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine |
Molecular weight | 318.863 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 5.2 |
Synonyms | 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine Prestwick3_000064 [ Show all ] |
Inchi Key | ZPEIMTDSQAKGNT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3 |
PubChem CID | 2726 |
ChEMBL | CHEMBL71 |
IUPHAR | 83 |
BindingDB | 50001888 |
DrugBank | DB00477 |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 57.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 4.0 nM | PMID12825922 | BindingDB,ChEMBL |
Ki | 12.0 nM | http://pdsp.med.unc.edu/pdsp.php | PDSP |
Ki | 15.8489 - 19.9526 nM | PMID8522988, PMID15821958 | IUPHAR |
Ki | 19.0 nM | PMID8522988 | PDSP,BindingDB |
Ki | 20.1 nM | PMID12629531 | PDSP,BindingDB |
Ki | 26.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | >50.0 nM | PMID15771424 | ChEMBL |
Ki | 50.12 nM | PMID17880057 | ChEMBL |
Ki | 60.0 nM | PMID24365159 | ChEMBL |
Ki | 60.26 nM | PMID24365159 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218