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GPCR

Name5-hydroxytryptamine receptor 6
SpeciesHomo sapiens (Human)
GeneHTR6
Synonym5-HT6 receptor
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
5-HT-6
serotonin receptor 6
ST-B17
[ Show all ]
DiseaseSchizophrenia
Obesity
Neurological disease
Neurodegenerative disease
Emesis
[ Show all ]
Length440
Amino acid sequenceMVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProtP50406
Protein Data BankN/A
GPCR-HGmod modelP50406
3D structure modelThis predicted structure model is from GPCR-EXP P50406.
BioLiPN/A
Therapeutic Target DatabaseT16691
ChEMBLCHEMBL3371
IUPHAR11
DrugBankBE0000945

Ligand

Namechlorpromazine
Molecular formulaC17H19ClN2S
IUPAC name3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight318.863
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.2
SynonymsDivK1c_000624
AB00051943
Esmind
ALBB-022464
HL 5746
[ Show all ]
Inchi KeyZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID2726
ChEMBLCHEMBL71
IUPHAR83
BindingDB50001888
DrugBankDB00477

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
IC5057.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki4.0 nMPMID12825922BindingDB,ChEMBL
Ki12.0 nMhttp://pdsp.med.unc.edu/pdsp.phpPDSP
Ki15.8489 - 19.9526 nMPMID8522988, PMID15821958IUPHAR
Ki19.0 nMPMID8522988PDSP,BindingDB
Ki20.1 nMPMID12629531PDSP,BindingDB
Ki26.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki>50.0 nMPMID15771424ChEMBL
Ki50.12 nMPMID17880057ChEMBL
Ki60.0 nMPMID24365159ChEMBL
Ki60.26 nMPMID24365159ChEMBL

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