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GPCR

Name	5-hydroxytryptamine receptor 1B
Species	Homo sapiens (Human)
Gene	HTR1B
Synonym	5-HT1B receptor 5-HT-1B 5-HT-1D-beta 5-HT1B Serotonin 1D beta receptor HTR1D2 5-HT1B serotonin receptor 5-HT1DB 5-HT1Dbeta 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled serotonin receptor 1B S12 [ Show all ]
Disease	Chronic schizophrenics Major depressive disorder Migraine headaches Mood disorder Psychotic disorders Anxiety disorder [ Show all ]
Length	390
Amino acid sequence	MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
UniProt	P28222
Protein Data Bank	4iar, 6g79, 5v54
GPCR-HGmod model	P28222
3D structure model	This structure is from PDB ID 4iar.
BioLiP	BL0239857, BL0403524,BL0403525, BL0417722
Therapeutic Target Database	T07806
ChEMBL	CHEMBL1898
IUPHAR	2
DrugBank	BE0000797

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine Psychozine DB00477 L000182 SCHEMBL8321 Epitope ID:136898 Lopac-C-8138 AKOS001490972 Spectrum2_001156 Hibernal (Salt/Mix) MolPort-001-727-953 AN-41563 Thorazine I14-6226 NCGC00015273-07 Bio1_000457 Tranzine (Salt/Mix) KBio2_003190 NCGC00015273-15 BSPBio_002011 ZPEIMTDSQAKGNT-UHFFFAOYSA-N KBioSS_000622 NCGC00024409-08 NSC167745 Chloropromazine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine Prestwick3_000064 cMAP_000017 Promapar Cromedazine 4560 R.P R1242 DSSTox_GSID_22808 Largactil Liquid AB00051943-16 SKF-2601 Fenaktyl M-1209 Aminazin Spectrum5_000717 HMS2089C12 NCGC00015273-02 BAS 00010434 Thorazine Spansule JHICC02042 NCGC00015273-10 Biomol-NT_000020 Unitensen KBio2_007448 NCGC00015273-19 CAS-50-53-3 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine KS-5101 Novo-Chlorpromazine Chlor-PZ (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Oprea1_110255 Chlorpromazin 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Plegomazin Chlorpromazinum 2601-A 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # Propaphenin D01ZII 50-53-3 SBI-0050237.P004 EINECS 200-045-8 Largactyl AB0015094 SPBio_002168 GG 407 Megaphen Amplicitil SR-01000000012-6 HMS501P06 NCGC00015273-05 BCP03610 Tox21_110120 KBio2_000622 NCGC00015273-13 BRD-K89997465-001-05-3 Z80 KBioGR_000806 NCGC00024409-06 CCRIS 3711 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) NSC-167745 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Phenathyl Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Prestwick1_000064 Clorpromazina [INN-Spanish] Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine QSPL 401 DivK1c_000624 Largactil AB00051943 SKF 2601-A Esmind Lopac0_000249 ALBB-022464 Spectrum3_000346 HL 5746 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine API0001970 Thorazine (TN) IDI1_000624 NCGC00015273-08 Bio1_000946 U42B7VYA4P KBio2_004880 NCGC00015273-16 C06906 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine KBioSS_002314 NINDS_000624 CHEMBL71 NSC17479 Chlorpromados 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina Proma Promazil CTK1C5154 4560 R.P. RP-4560 DSSTox_RID_76736 Largactil Oral Drops AB00051943_17 SMR001453710 Fraction AB M176 Aminazine Spectrum_000142 HMS2091E06 NCGC00015273-03 BBL028251 Thorazine Suppositories KB-232587 NCGC00015273-11 BPBio1_000273 Wintermin KBio3_001231 NCGC00024409-04 CAS-69-09-0 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) KSC-315-032- Novomazina Chlordelazine (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Pharmakon1600-01500184 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Prazilpromactil Chlorpromazinum [INN-Latin] 2601A 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Prozil SC-50091 Elmarin Lomazine (Salt/Mix) AC1L1EBT SPECTRUM1500184 GTPL83 MLS003166901 Amplictil STK182870 HSDB 3033 NCGC00015273-06 BDBM50001888 Tox21_110120_1 KBio2_002312 NCGC00015273-14 BSPBio_000247 ZINC44027 KBioGR_002312 NCGC00024409-07 CHEBI:3647 NSC-756689 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Phenothiazine hydrochloride Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Prestwick2_000064 Clorpromazina [Italian] CPZ 34468-21-8 QTL1_000021 DSSTox_CID_2808 Largactil (TN) AB00051943-15 SKF 2601A Fenactil LS-105361 Aminasine Spectrum4_000283 HMS1920M03 NCGC00015273-01 AX8120990 Thorazine hydrochloride J10069 NCGC00015273-09 Bio1_001435 UNII-U42B7VYA4P KBio2_005758 NCGC00015273-17 C17H19ClN2S [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride KS-00002WW5 Norcozine (Salt/Mix) Chlor-Promanyl NSC756689 Chlorpromanyl (discontinued) 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Plegomasine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] Promactil 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine Propaphen D00270 4560 Rp hydrochloride Sanopron DTXSID0022808 Largactilothiazine AB00051943_18 SPBio_001111 FT-0653683 MCULE-5976054678 Ampliactil SR-01000000012-5 HMS3430C19 NCGC00015273-04 BC 135 Torazina KBio1_000624 NCGC00015273-12 BPBio1_001181 WLN: T C666 BN ISJ B3N1&1 EG KBio3_002792 NCGC00024409-05 CCG-40059 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) KUC112482N NSC 167745 Chlorderazin Phenactyl Chlorpromazine (USP/INN) 2-chloro-10-[3-(dimethylamino)propyl]- Prestwick0_000064 Clorpromazina [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1489.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP

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