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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesHomo sapiens (Human)
GeneHTR7
Synonym5-HT-7
Serotonin receptor 7
5-HT-X
5-HT1Y
5-HT7
[ Show all ]
DiseaseSleep disorders
Schizophrenia
Major depressive disorder
Length479
Amino acid sequenceMMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProtP34969
Protein Data BankN/A
GPCR-HGmod modelP34969
3D structure modelThis predicted structure model is from GPCR-EXP P34969.
BioLiPN/A
Therapeutic Target DatabaseT79062
ChEMBLCHEMBL3155
IUPHAR12
DrugBankBE0000650, BE0004862

Ligand

Namechlorpromazine
Molecular formulaC17H19ClN2S
IUPAC name3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight318.863
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.2
SynonymsSR-01000000012-6
HMS3430C19
NCGC00015273-05
BC 135
Tox21_110120
[ Show all ]
Inchi KeyZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID2726
ChEMBLCHEMBL71
IUPHAR83
BindingDB50001888
DrugBankDB00477

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
N/A N/ADrugBank
Ki10.72 nMPMID23541835ChEMBL
Ki11.0 nMPMID23541835BindingDB,ChEMBL
Ki21.0 nMhttp://pdsp.med.unc.edu/pdsp.phpPDSP
Ki25.1189 nMPMID15821958IUPHAR
Ki27.0 nMPMID21907583BindingDB,ChEMBL
Ki31.62 nMPMID17880057ChEMBL
Ki35.8 nMPMID12629531PDSP,BindingDB
Ki119.0 nMPMID24365159ChEMBL
Ki120.23 nMPMID24365159ChEMBL
Ki480.0 nMPMID28719185BindingDB

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