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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Homo sapiens (Human)
Gene	HTR7
Synonym	5-HT-7 Serotonin receptor 7 5-HT-X 5-HT1Y 5-HT7 GPRFO 5-HT7 receptor 5-HTx 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Show all ]
Disease	Sleep disorders Schizophrenia Major depressive disorder
Length	479
Amino acid sequence	MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProt	P34969
Protein Data Bank	N/A
GPCR-HGmod model	P34969
3D structure model	This predicted structure model is from GPCR-EXP P34969.
BioLiP	N/A
Therapeutic Target Database	T79062
ChEMBL	CHEMBL3155
IUPHAR	12
DrugBank	BE0000650, BE0004862

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	CPZ 34468-21-8 DSSTox_CID_2808 AB00051943-15 Fenactil Aminasine HMS1920M03 AX8120990 J10069 Bio1_001435 KBio2_005758 C17H19ClN2S KS-00002WW5 Chlor-Promanyl Chlorpromanyl (discontinued) 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] Norcozine (Salt/Mix) NSC756689 Plegomasine Promactil QTL1_000021 Largactil (TN) SKF 2601A LS-105361 Spectrum4_000283 NCGC00015273-01 Thorazine hydrochloride NCGC00015273-09 UNII-U42B7VYA4P NCGC00015273-17 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine D00270 4560 Rp hydrochloride DTXSID0022808 AB00051943_18 FT-0653683 Ampliactil HMS3430C19 BC 135 KBio1_000624 BPBio1_001181 KBio3_002792 CCG-40059 KUC112482N Chlorderazin Chlorpromazine (USP/INN) 2-chloro-10-[3-(dimethylamino)propyl]- Clorpromazina NSC 167745 Phenactyl Prestwick0_000064 Propaphen Sanopron Largactilothiazine SPBio_001111 MCULE-5976054678 SR-01000000012-5 NCGC00015273-04 Torazina NCGC00015273-12 WLN: T C666 BN ISJ B3N1&1 EG NCGC00024409-05 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) cMAP_000017 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine DB00477 Epitope ID:136898 AKOS001490972 Hibernal (Salt/Mix) AN-41563 I14-6226 Bio1_000457 KBio2_003190 BSPBio_002011 KBioSS_000622 Chloropromazine 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Chlorpromazine [USAN:INN:BAN] 2-Chloropromazine NSC167745 Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Prestwick3_000064 Psychozine L000182 SCHEMBL8321 Lopac-C-8138 Spectrum2_001156 MolPort-001-727-953 Thorazine NCGC00015273-07 Tranzine (Salt/Mix) NCGC00015273-15 ZPEIMTDSQAKGNT-UHFFFAOYSA-N NCGC00024409-08 2601-A Cromedazine 4560 R.P DSSTox_GSID_22808 AB00051943-16 Fenaktyl Aminazin HMS2089C12 BAS 00010434 JHICC02042 Biomol-NT_000020 KBio2_007448 CAS-50-53-3 KS-5101 Chlor-PZ (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Chlorpromazin 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Chlorpromazinum Novo-Chlorpromazine Oprea1_110255 Plegomazin Promapar R1242 Largactil Liquid SKF-2601 M-1209 Spectrum5_000717 NCGC00015273-02 Thorazine Spansule NCGC00015273-10 Unitensen NCGC00015273-19 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # D01ZII 50-53-3 EINECS 200-045-8 AB0015094 GG 407 Amplicitil HMS501P06 BCP03610 KBio2_000622 BRD-K89997465-001-05-3 KBioGR_000806 CCRIS 3711 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Chlorpromazine cation radical 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Clorpromazina [INN-Spanish] [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) NSC-167745 Phenathyl Prestwick1_000064 Propaphenin SBI-0050237.P004 Largactyl SPBio_002168 Megaphen SR-01000000012-6 NCGC00015273-05 Tox21_110120 NCGC00015273-13 Z80 NCGC00024409-06 Contomin 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine DivK1c_000624 AB00051943 Esmind ALBB-022464 HL 5746 API0001970 IDI1_000624 Bio1_000946 KBio2_004880 C06906 KBioSS_002314 CHEMBL71 Chlorpromados 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Chlorpromazine [USP:INN:BAN] 2-Cloro-10 (3-dimetilaminopropil)fenotiazina NSC17479 Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Proma QSPL 401 Largactil SKF 2601-A Lopac0_000249 Spectrum3_000346 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Thorazine (TN) NCGC00015273-08 U42B7VYA4P NCGC00015273-16 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine NINDS_000624 2601A CTK1C5154 4560 R.P. DSSTox_RID_76736 AB00051943_17 Fraction AB Aminazine HMS2091E06 BBL028251 KB-232587 BPBio1_000273 KBio3_001231 CAS-69-09-0 KSC-315-032- Chlordelazine (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Chlorpromazinum [INN-Latin] Novomazina Pharmakon1600-01500184 Prazilpromactil Promazil RP-4560 Largactil Oral Drops SMR001453710 M176 Spectrum_000142 NCGC00015273-03 Thorazine Suppositories NCGC00015273-11 Wintermin NCGC00024409-04 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) Clorpromazina [Italian] 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Elmarin AC1L1EBT GTPL83 Amplictil HSDB 3033 BDBM50001888 KBio2_002312 BSPBio_000247 KBioGR_002312 CHEBI:3647 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Chlorpromazine Tannate 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine NSC-756689 Phenothiazine hydrochloride Prestwick2_000064 Prozil SC-50091 Lomazine (Salt/Mix) SPECTRUM1500184 MLS003166901 STK182870 NCGC00015273-06 Tox21_110120_1 NCGC00015273-14 ZINC44027 NCGC00024409-07 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	10.72 nM	PMID23541835	ChEMBL
Ki	11.0 nM	PMID23541835	BindingDB,ChEMBL
Ki	21.0 nM	http://pdsp.med.unc.edu/pdsp.php	PDSP
Ki	25.1189 nM	PMID15821958	IUPHAR
Ki	27.0 nM	PMID21907583	BindingDB,ChEMBL
Ki	31.62 nM	PMID17880057	ChEMBL
Ki	35.8 nM	PMID12629531	PDSP,BindingDB
Ki	119.0 nM	PMID24365159	ChEMBL
Ki	120.23 nM	PMID24365159	ChEMBL
Ki	480.0 nM	PMID28719185	BindingDB

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