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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Mus musculus (Mouse)
Gene	Htr6
Synonym	5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 ST-B17 [ Show all ]
Disease	N/A for non-human GPCRs
Length	440
Amino acid sequence	MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTSAPGQCRLLASLPYVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTATAGQALETLQVPRTPRPGMESADSRRLTTKHSRKALKASLTLGILLSMFFVTWLPFFVASIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFVPCVHCPPEHRASPASPSMWTSHSGARPGLSLQQVLPLPLPPNSDSDSASGGTSGLQLTAQLLLPGEATRDPPPPTRAPTVVNFFVTDSVEPEIRQHPLGSPMN
UniProt	Q9R1C8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075268
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Elmarin [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine AC1L1EBT NINDS_000624 GTPL83 Amplictil NSC17479 HSDB 3033 BDBM50001888 Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- KBio2_002312 BSPBio_000247 Proma KBioGR_002312 CHEBI:3647 QSPL 401 Largactil Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] SKF 2601-A 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Lopac0_000249 Chlorpromazine Tannate Spectrum3_000346 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine N-(3-Dimethylaminopropyl)-3-chlorophenothiazine Clorpromazina [Italian] Thorazine (TN) 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine NCGC00015273-08 U42B7VYA4P NCGC00015273-16 NCGC00024409-04 Fenactil [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) Aminasine Novomazina HMS1920M03 AX8120990 Pharmakon1600-01500184 J10069 Bio1_001435 Prazilpromactil KBio2_005758 C17H19ClN2S Promazil KS-00002WW5 Chlor-Promanyl RP-4560 Largactil Oral Drops Chlorpromanyl (discontinued) SMR001453710 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine M176 Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Spectrum_000142 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] NCGC00015273-03 CPZ Thorazine Suppositories 34468-21-8 NCGC00015273-11 DSSTox_CID_2808 Wintermin AB00051943-15 ZINC44027 AB00051943_18 NCGC00024409-07 FT-0653683 Ampliactil NSC-756689 HMS3430C19 BC 135 Phenothiazine hydrochloride KBio1_000624 BPBio1_001181 Prestwick2_000064 KBio3_002792 CCG-40059 Prozil KUC112482N Chlorderazin SC-50091 Lomazine (Salt/Mix) Chlorpromazine (USP/INN) SPECTRUM1500184 2-chloro-10-[3-(dimethylamino)propyl]- MLS003166901 Clorpromazina STK182870 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine NCGC00015273-06 D00270 Tox21_110120_1 4560 Rp hydrochloride NCGC00015273-14 DTXSID0022808 Epitope ID:136898 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride AKOS001490972 Norcozine (Salt/Mix) Hibernal (Salt/Mix) AN-41563 NSC756689 I14-6226 Bio1_000457 Plegomasine KBio2_003190 BSPBio_002011 Promactil KBioSS_000622 QTL1_000021 Largactil (TN) Chloropromazine SKF 2601A 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) LS-105361 Chlorpromazine [USAN:INN:BAN] Spectrum4_000283 2-Chloropromazine NCGC00015273-01 cMAP_000017 Thorazine hydrochloride 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine NCGC00015273-09 DB00477 UNII-U42B7VYA4P NCGC00015273-17 NCGC00024409-05 Fenaktyl [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) Aminazin NSC 167745 HMS2089C12 BAS 00010434 Phenactyl JHICC02042 Biomol-NT_000020 Prestwick0_000064 KBio2_007448 CAS-50-53-3 Propaphen KS-5101 Chlor-PZ Sanopron (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Largactilothiazine Chlorpromazin SPBio_001111 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine MCULE-5976054678 Chlorpromazinum SR-01000000012-5 2601-A NCGC00015273-04 Cromedazine Torazina 4560 R.P NCGC00015273-12 DSSTox_GSID_22808 WLN: T C666 BN ISJ B3N1&1 EG AB00051943-16 ZPEIMTDSQAKGNT-UHFFFAOYSA-N AB0015094 NCGC00024409-08 GG 407 Amplicitil NSC167745 HMS501P06 BCP03610 Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- KBio2_000622 BRD-K89997465-001-05-3 Prestwick3_000064 KBioGR_000806 CCRIS 3711 Psychozine L000182 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine SCHEMBL8321 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Lopac-C-8138 Chlorpromazine cation radical Spectrum2_001156 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine MolPort-001-727-953 Clorpromazina [INN-Spanish] Thorazine 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # NCGC00015273-07 D01ZII Tranzine (Salt/Mix) 50-53-3 NCGC00015273-15 EINECS 200-045-8 Esmind [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine ALBB-022464 Novo-Chlorpromazine HL 5746 API0001970 Oprea1_110255 IDI1_000624 Bio1_000946 Plegomazin KBio2_004880 C06906 Promapar KBioSS_002314 CHEMBL71 R1242 Largactil Liquid Chlorpromados SKF-2601 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine M-1209 Chlorpromazine [USP:INN:BAN] Spectrum5_000717 2-Cloro-10 (3-dimetilaminopropil)fenotiazina NCGC00015273-02 Contomin Thorazine Spansule 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine NCGC00015273-10 DivK1c_000624 Unitensen AB00051943 NCGC00015273-19 AB00051943_17 NCGC00024409-06 Fraction AB [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) Aminazine NSC-167745 HMS2091E06 BBL028251 Phenathyl KB-232587 BPBio1_000273 Prestwick1_000064 KBio3_001231 CAS-69-09-0 Propaphenin KSC-315-032- Chlordelazine SBI-0050237.P004 (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Largactyl SPBio_002168 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Megaphen Chlorpromazinum [INN-Latin] SR-01000000012-6 2601A NCGC00015273-05 CTK1C5154 Tox21_110120 4560 R.P. NCGC00015273-13 DSSTox_RID_76736 Z80 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5011.87 nM	PMID8394987	BindingDB

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