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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 2B
Species	Homo sapiens (Human)
Gene	HTR2B
Synonym	stomach fundus serotonin receptor serotonin receptor 2B 5-HT2F 5-HT-2B 5-HT2B 5-HT2B receptor 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled [ Show all ]
Disease	Psychoses Migraine Irritable bowel syndrome Depression; Cerebral infarction Coronary heart disease Congestive heart failure Pulmonary arterial hypertension [ Show all ]
Length	481
Amino acid sequence	MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
UniProt	P41595
Protein Data Bank	5tud, 5tvn, 6drx, 4ib4, 4nc3, 6dry, 6drz, 6ds0
GPCR-HGmod model	P41595
3D structure model	This structure is from PDB ID 5tud.
BioLiP	BL0425280, BL0425283, BL0425282, BL0239858, BL0239859, BL0265182, BL0265183, BL0368464, BL0425281, BL0385686,BL0385687, BL0425284, BL0425285, BL0425286, BL0368465, BL0425287
Therapeutic Target Database	T31204
ChEMBL	CHEMBL1833
IUPHAR	7
DrugBank	BE0000393

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Chlorpromazine Tannate Promapar 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine Clorpromazina [Italian] R1242 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine Largactil Liquid SKF-2601 M-1209 Elmarin Spectrum5_000717 AC1L1EBT NCGC00015273-02 GTPL83 Thorazine Spansule Amplictil NCGC00015273-10 HSDB 3033 Unitensen BDBM50001888 NCGC00015273-19 KBio2_002312 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine BSPBio_000247 Novo-Chlorpromazine KBioGR_002312 CHEBI:3647 Oprea1_110255 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] Plegomazin 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Propaphenin 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] CPZ SBI-0050237.P004 34468-21-8 Largactyl DSSTox_CID_2808 SPBio_002168 AB00051943-15 Megaphen Fenactil SR-01000000012-6 Aminasine NCGC00015273-05 HMS1920M03 Tox21_110120 AX8120990 NCGC00015273-13 J10069 Z80 Bio1_001435 NCGC00024409-06 KBio2_005758 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) C17H19ClN2S NSC-167745 KS-00002WW5 Chlor-Promanyl Phenathyl Chlorpromanyl (discontinued) Prestwick1_000064 Proma 2-chloro-10-[3-(dimethylamino)propyl]- Clorpromazina QSPL 401 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine Largactil D00270 SKF 2601-A 4560 Rp hydrochloride Lopac0_000249 DTXSID0022808 Spectrum3_000346 AB00051943_18 N-(3-Dimethylaminopropyl)-3-chlorophenothiazine FT-0653683 Thorazine (TN) Ampliactil NCGC00015273-08 HMS3430C19 U42B7VYA4P BC 135 NCGC00015273-16 KBio1_000624 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine BPBio1_001181 NINDS_000624 KBio3_002792 CCG-40059 NSC17479 KUC112482N Chlorderazin Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Chlorpromazine (USP/INN) Chlorpromazine [USAN:INN:BAN] Promazil 2-Chloropromazine cMAP_000017 RP-4560 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine Largactil Oral Drops DB00477 SMR001453710 M176 Epitope ID:136898 Spectrum_000142 AKOS001490972 NCGC00015273-03 Hibernal (Salt/Mix) Thorazine Suppositories AN-41563 NCGC00015273-11 I14-6226 Wintermin Bio1_000457 NCGC00024409-04 KBio2_003190 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) BSPBio_002011 Novomazina KBioSS_000622 Pharmakon1600-01500184 Chloropromazine Prazilpromactil 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Prestwick2_000064 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Chlorpromazinum Prozil 2601-A Cromedazine SC-50091 4560 R.P Lomazine (Salt/Mix) DSSTox_GSID_22808 SPECTRUM1500184 AB00051943-16 MLS003166901 Fenaktyl STK182870 Aminazin NCGC00015273-06 HMS2089C12 Tox21_110120_1 BAS 00010434 NCGC00015273-14 JHICC02042 ZINC44027 Biomol-NT_000020 NCGC00024409-07 KBio2_007448 CAS-50-53-3 NSC-756689 KS-5101 Chlor-PZ Phenothiazine hydrochloride (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Chlorpromazin Chlorpromazine cation radical Promactil 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Clorpromazina [INN-Spanish] QTL1_000021 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # Largactil (TN) D01ZII SKF 2601A 50-53-3 LS-105361 EINECS 200-045-8 Spectrum4_000283 AB0015094 NCGC00015273-01 GG 407 Thorazine hydrochloride Amplicitil NCGC00015273-09 HMS501P06 UNII-U42B7VYA4P BCP03610 NCGC00015273-17 KBio2_000622 [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride BRD-K89997465-001-05-3 Norcozine (Salt/Mix) KBioGR_000806 CCRIS 3711 NSC756689 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine Plegomasine 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Chlorpromazine [USP:INN:BAN] Propaphen 2-Cloro-10 (3-dimetilaminopropil)fenotiazina Contomin Sanopron 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine Largactilothiazine DivK1c_000624 SPBio_001111 AB00051943 MCULE-5976054678 Esmind SR-01000000012-5 ALBB-022464 NCGC00015273-04 HL 5746 Torazina API0001970 NCGC00015273-12 IDI1_000624 WLN: T C666 BN ISJ B3N1&1 EG Bio1_000946 NCGC00024409-05 KBio2_004880 [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) C06906 NSC 167745 KBioSS_002314 CHEMBL71 Phenactyl Chlorpromados Prestwick0_000064 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Prestwick3_000064 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine Chlorpromazinum [INN-Latin] Psychozine 2601A L000182 CTK1C5154 SCHEMBL8321 4560 R.P. Lopac-C-8138 DSSTox_RID_76736 Spectrum2_001156 AB00051943_17 MolPort-001-727-953 Fraction AB Thorazine Aminazine NCGC00015273-07 HMS2091E06 Tranzine (Salt/Mix) BBL028251 NCGC00015273-15 KB-232587 ZPEIMTDSQAKGNT-UHFFFAOYSA-N BPBio1_000273 NCGC00024409-08 KBio3_001231 CAS-69-09-0 NSC167745 KSC-315-032- Chlordelazine Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	126.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	39.81 nM	PMID17880057	ChEMBL
Ki	52.0 nM	PMID20958049	BindingDB,ChEMBL
Ki	80.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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