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GLASS

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GPCR

Name	Alpha-1A adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA1A
Synonym	alpha1a ADRA1C ADRA1L1 adrenergic alpha 1c receptor adrenergic receptor alpha 1c adrenergic receptor, alpha 1a alpha 1A-adrenoceptor alpha 1A-adrenoreceptor alpha1c alpha 1C-adrenergic receptor alpha-1A adrenergic receptor Alpha-1A adrenoceptor Alpha-1A adrenoreceptor Alpha-1C adrenergic receptor Alpha-adrenergic receptor 1c alpha1A-adrenoceptor [ Show all ]
Disease	Urinary incontinence Benign prostatic hyperplasia Cognitive disorders Female sexual dysfunction Glaucoma Hypertension Major depressive disorder Pain Post-traumatic stress disorder Prostate cancer; Benign prostatic hyperplasia Prostate disease Prostate hyperplasia Stress urinary incontinence Unspecified [ Show all ]
Length	466
Amino acid sequence	MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
UniProt	P35348
Protein Data Bank	N/A
GPCR-HGmod model	P35348
3D structure model	This predicted structure model is from GPCR-EXP P35348.
BioLiP	N/A
Therapeutic Target Database	T92609
ChEMBL	CHEMBL229
IUPHAR	22
DrugBank	BE0000501

Ligand

Name	chlorpromazine
Molecular formula	C17H19ClN2S
IUPAC name	3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
Molecular weight	318.863
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	Chlordelazine NCGC00015273-01 (chlorpromazine)[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Thorazine hydrochloride NCGC00015273-09 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine UNII-U42B7VYA4P Chlorpromazinum [INN-Latin] NCGC00015273-17 2601A [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine hydrochloride CTK1C5154 Norcozine (Salt/Mix) 4560 R.P. DSSTox_RID_76736 NSC756689 AB00051943_17 Fraction AB Plegomasine Aminazine HMS2091E06 Promactil BBL028251 KB-232587 QTL1_000021 BPBio1_000273 Largactil (TN) KBio3_001231 SKF 2601A CAS-69-09-0 LS-105361 KSC-315-032- Spectrum4_000283 SR-01000000012-5 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French] NCGC00015273-04 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl- Torazina Chlorpromazine Tannate NCGC00015273-12 2-chloro-N,N-dimethyl-10H-Phenothiazine-10-propanamine WLN: T C666 BN ISJ B3N1&1 EG Clorpromazina [Italian] NCGC00024409-05 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine( Chlorpromazine) NSC 167745 Elmarin Phenactyl AC1L1EBT GTPL83 Prestwick0_000064 Amplictil HSDB 3033 Propaphen BDBM50001888 KBio2_002312 Sanopron BSPBio_000247 Largactilothiazine KBioGR_002312 SPBio_001111 CHEBI:3647 MCULE-5976054678 MolPort-001-727-953 Thorazine Chlorpromanyl (discontinued) NCGC00015273-07 2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine Tranzine (Salt/Mix) Chlorpromazine;[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine NCGC00015273-15 2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian] ZPEIMTDSQAKGNT-UHFFFAOYSA-N CPZ NCGC00024409-08 34468-21-8 DSSTox_CID_2808 NSC167745 AB00051943-15 Fenactil Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)- Aminasine HMS1920M03 Prestwick3_000064 AX8120990 J10069 Psychozine Bio1_001435 L000182 KBio2_005758 SCHEMBL8321 C17H19ClN2S Lopac-C-8138 KS-00002WW5 Spectrum2_001156 Chlor-Promanyl Chlorderazin NCGC00015273-02 Thorazine Spansule Chlorpromazine (USP/INN) NCGC00015273-10 2-chloro-10-[3-(dimethylamino)propyl]- Unitensen Clorpromazina NCGC00015273-19 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine D00270 Novo-Chlorpromazine 4560 Rp hydrochloride DTXSID0022808 Oprea1_110255 AB00051943_18 FT-0653683 Plegomazin Ampliactil HMS3430C19 Promapar BC 135 KBio1_000624 R1242 BPBio1_001181 Largactil Liquid KBio3_002792 SKF-2601 CCG-40059 M-1209 KUC112482N Spectrum5_000717 SR-01000000012-6 Chloropromazine NCGC00015273-05 10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+) Tox21_110120 Chlorpromazine [USAN:INN:BAN] NCGC00015273-13 2-Chloropromazine Z80 cMAP_000017 NCGC00024409-06 3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine(clorpromazine) DB00477 NSC-167745 Epitope ID:136898 Phenathyl AKOS001490972 Hibernal (Salt/Mix) Prestwick1_000064 AN-41563 I14-6226 Propaphenin Bio1_000457 KBio2_003190 SBI-0050237.P004 BSPBio_002011 Largactyl KBioSS_000622 SPBio_002168 Megaphen N-(3-Dimethylaminopropyl)-3-chlorophenothiazine (chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine Thorazine (TN) Chlorpromazin NCGC00015273-08 2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine U42B7VYA4P Chlorpromazinum NCGC00015273-16 2601-A [3-(2-chloro-10H-phenothiazin-10-yl)propyl]dimethylamine Cromedazine NINDS_000624 4560 R.P DSSTox_GSID_22808 NSC17479 AB00051943-16 Fenaktyl Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]- Aminazin HMS2089C12 Proma BAS 00010434 JHICC02042 QSPL 401 Biomol-NT_000020 Largactil KBio2_007448 SKF 2601-A CAS-50-53-3 Lopac0_000249 KS-5101 Spectrum3_000346 Chlor-PZ Spectrum_000142 Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine NCGC00015273-03 10-(3-Dimethylaminopropyl)-2-chlorophenothiazine Thorazine Suppositories Chlorpromazine cation radical NCGC00015273-11 2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine Wintermin Clorpromazina [INN-Spanish] NCGC00024409-04 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine # [3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine (chlor-promazine) D01ZII Novomazina 50-53-3 EINECS 200-045-8 Pharmakon1600-01500184 AB0015094 GG 407 Prazilpromactil Amplicitil HMS501P06 Promazil BCP03610 KBio2_000622 RP-4560 BRD-K89997465-001-05-3 Largactil Oral Drops KBioGR_000806 SMR001453710 CCRIS 3711 M176 STK182870 Chlorpromados NCGC00015273-06 1N,1N-dimethyl-3-(2-chloro-10H-10-phenothiazinyl)-1-propanamine Tox21_110120_1 Chlorpromazine [USP:INN:BAN] NCGC00015273-14 2-Cloro-10 (3-dimetilaminopropil)fenotiazina ZINC44027 Contomin NCGC00024409-07 3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine DivK1c_000624 NSC-756689 AB00051943 Esmind Phenothiazine hydrochloride ALBB-022464 HL 5746 Prestwick2_000064 API0001970 IDI1_000624 Prozil Bio1_000946 KBio2_004880 SC-50091 C06906 Lomazine (Salt/Mix) KBioSS_002314 SPECTRUM1500184 CHEMBL71 MLS003166901 [ Show all ]
Inchi Key	ZPEIMTDSQAKGNT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
PubChem CID	2726
ChEMBL	CHEMBL71
IUPHAR	83
BindingDB	50001888
DrugBank	DB00477
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
Ki	0.28 nM	PMID12629531, http://pdsp.med.unc.edu/pdsp.php	PDSP,BindingDB
Ki	2.63 nM	PMID2904784	BindingDB

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