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GPCR

NameSphingosine 1-phosphate receptor 4
SpeciesHomo sapiens (Human)
GeneS1PR4
SynonymS1P4 receptor
S1P4
S1P receptor Edg-6
S1P receptor 4
endothelial differentiation, G protein-coupled receptor 6
[ Show all ]
DiseaseN/A
Length384
Amino acid sequenceMNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
UniProtO95977
Protein Data BankN/A
GPCR-HGmod modelO95977
3D structure modelThis predicted structure model is from GPCR-EXP O95977.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3230
IUPHAR278
DrugBankN/A

Ligand

NameCHEMBL537632
Molecular formulaC20H31N3O2
IUPAC name2-amino-2-[5-(4-octylphenyl)-1H-imidazol-2-yl]propane-1,3-diol
Molecular weight345.487
Hydrogen bond acceptor4
Hydrogen bond donor4
XlogP3.2
SynonymsBDBM50169456
2-Amino-2-[5-(4-octyl-phenyl)-1H-imidazol-2-yl]-propane-1,3-diol; hydrochloride
CHEMBL1188885
Inchi KeyAFOKUYNUCQYJRC-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H31N3O2/c1-2-3-4-5-6-7-8-16-9-11-17(12-10-16)18-13-22-19(23-18)20(21,14-24)15-25/h9-13,24-25H,2-8,14-15,21H2,1H3,(H,22,23)
PubChem CID44398074
ChEMBLN/A
IUPHARN/A
BindingDB50169456
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50660.0 nMPMID15982878BindingDB

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