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Name | D(2) dopamine receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Drd2 |
Synonym | D2 receptor D2(415) and D2(444) D2A and D2B D2R Dopamine D2 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 444 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC |
UniProt | P61169 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL339 |
IUPHAR | 215 |
DrugBank | N/A |
Name | dinapsoline |
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Molecular formula | C16H15NO2 |
IUPAC name | (1S)-15-azatetracyclo[7.7.1.02,7.013,17]heptadeca-2(7),3,5,9(17),10,12-hexaene-5,6-diol |
Molecular weight | 253.301 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 3 |
XlogP | 2.1 |
Synonyms | SCHEMBL16938669 CHEMBL124561 (S)-2,3,7,11b-Tetrahydro-1H-dibenzo[de,h]isoquinoline-8,9-diol Dinapsoline, (R)(+) BDBM50117181 [ Show all ] |
Inchi Key | ZQTSNGJHMUKLOM-ZDUSSCGKSA-N |
Inchi ID | InChI=1S/C16H15NO2/c18-14-5-4-11-12(16(14)19)6-9-2-1-3-10-7-17-8-13(11)15(9)10/h1-5,13,17-19H,6-8H2/t13-/m0/s1 |
PubChem CID | 9816455 |
ChEMBL | CHEMBL124561 |
IUPHAR | N/A |
BindingDB | 50117181 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 38.0 nM | PMID12166939 | BindingDB,ChEMBL |
K 0.5 | 31.3 nM | PMID10072690 | ChEMBL |
K 0.5 | 174.0 nM | PMID10072690 | ChEMBL |
K0.5 | 31.3 nM | PMID8558526 | ChEMBL |
Ki | 25.0 nM | PMID12628671 | BindingDB |
Ki | 31.3 nM | PMID8558526 | BindingDB |
Ki | 38.0 nM | PMID14759732 | BindingDB |
Ki | 53.0 nM | PMID12628671 | BindingDB |
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