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GPCR

NameProstaglandin D2 receptor 2
SpeciesMus musculus (Mouse)
GenePtgdr2
SynonymPGD2 receptor
Gpr44
G-protein coupled receptor 44
G protein-coupled receptor 44
DP2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length382
Amino acid sequenceMANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
UniProtQ9Z2J6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2291
IUPHAR339
DrugBankN/A

Ligand

NameCHEMBL2204469
Molecular formulaC23H18F3N3O3
IUPAC name2-[3-[[1-[(2,4-difluorophenyl)methyl]-6-oxopyridazin-3-yl]methyl]-5-fluoro-2-methylindol-1-yl]acetic acid
Molecular weight441.41
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP3.3
SynonymsBCP18118
2-(3-((1-(2,4-difluorobenzyl)-6-oxo-1,6-dihydropyridazin-3-yl)methyl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid
BDBM50401097
1297276-84-6
SCHEMBL1757725
[ Show all ]
Inchi KeyZTPOWDSDKMQVBU-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H18F3N3O3/c1-13-18(19-8-15(24)4-6-21(19)28(13)12-23(31)32)10-17-5-7-22(30)29(27-17)11-14-2-3-16(25)9-20(14)26/h2-9H,10-12H2,1H3,(H,31,32)
PubChem CID52920263
ChEMBLCHEMBL2204469
IUPHARN/A
BindingDB50401097
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC507.0 nMPMID22651823BindingDB,ChEMBL

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