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GPCR

NameN-formyl peptide receptor 2
SpeciesHomo sapiens (Human)
GeneFPR2
SynonymFPRH1
FPRH2
FPRL1
HM63
Lipoxin A4 receptor
[ Show all ]
DiseaseN/A
Length351
Amino acid sequenceMETNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProtP25090
Protein Data BankN/A
GPCR-HGmod modelP25090
3D structure modelThis predicted structure model is from GPCR-EXP P25090.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4227
IUPHAR223
DrugBankN/A

Ligand

NameUNM000003539401
Molecular formulaC23H15F3O7
IUPAC name[3-(3,4-dimethoxyphenyl)-4-oxo-2-(trifluoromethyl)chromen-7-yl] furan-2-carboxylate
Molecular weight460.361
Hydrogen bond acceptor10
Hydrogen bond donor0
XlogP4.8
Synonyms3-(3,4-dimethoxyphenyl)-4-oxo-2-(trifluoromethyl)-4H-chromen-7-yl furan-2-carboxylate
BDBM40413
MCULE-6418690008
[3-(3,4-dimethoxyphenyl)-4-oxidanylidene-2-(trifluoromethyl)chromen-7-yl] furan-2-carboxylate
CHEMBL1473100
[ Show all ]
Inchi KeyAFRGGYNZKHADNN-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H15F3O7/c1-29-15-8-5-12(10-18(15)30-2)19-20(27)14-7-6-13(32-22(28)16-4-3-9-31-16)11-17(14)33-21(19)23(24,25)26/h3-11H,1-2H3
PubChem CID1036463
ChEMBLCHEMBL1473100
IUPHARN/A
BindingDB40413
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<40300.0 nMN/ABindingDB

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