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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL295689
Molecular formulaC13H16N4O
IUPAC name4-(furan-2-yl)-2-(4-methylpiperazin-1-yl)pyrimidine
Molecular weight244.298
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP1.2
SynonymsBDBM50289604
4-Furan-2-yl-2-(4-methyl-piperazin-1-yl)-pyrimidine
1-[4-(2-Furanyl)pyrimidin-2-yl]-4-methylpiperazine
Inchi KeyAFRJNNKMRAFXSE-UHFFFAOYSA-N
Inchi IDInChI=1S/C13H16N4O/c1-16-6-8-17(9-7-16)13-14-5-4-11(15-13)12-3-2-10-18-12/h2-5,10H,6-9H2,1H3
PubChem CID10444523
ChEMBLCHEMBL295689
IUPHARN/A
BindingDB50289604
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki810.0 nM, Bioorg. Med. Chem. Lett., (1997) 7:13:1635BindingDB,ChEMBL

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