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GPCR

NameAdenosine receptor A3
SpeciesHomo sapiens (Human)
GeneADORA3
SynonymARA3
Adenosine receptor A3
A3AR
A3 receptor
TGPCR1
DiseaseCerebrovascular ischaemia
Malaria
Ischemia
Inflammation
Hepatocellular carcinoma; Hepatitis C virus infection
[ Show all ]
Length318
Amino acid sequenceMPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
UniProtP0DMS8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT36059
ChEMBLCHEMBL256
IUPHAR21
DrugBankBE0000354

Ligand

NameCHEMBL3087709
Molecular formulaC23H17N5O2
IUPAC nameN-[8-(furan-2-yl)-9-methylpurin-6-yl]-4-phenylbenzamide
Molecular weight395.422
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.6
SynonymsN/A
Inchi KeyAFPYJJLDUPLMID-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H17N5O2/c1-28-21(18-8-5-13-30-18)26-19-20(24-14-25-22(19)28)27-23(29)17-11-9-16(10-12-17)15-6-3-2-4-7-15/h2-14H,1H3,(H,24,25,27,29)
PubChem CID76313599
ChEMBLCHEMBL3087709
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki20285.0 nMPMID24189496ChEMBL

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