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GPCR

NameD(2) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD2
Synonymdopamine receptor 2
Dopamine D2 receptor
D2R
D2A and D2B
D2(415) and D2(444)
[ Show all ]
DiseaseSubstance dependence
Major depressive disorder
Maintain blood pressure in hypotensive states
Insomnia
Inflammatory disease
[ Show all ]
Length443
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP14416
Protein Data Bank6cm4, 6c38
GPCR-HGmod modelP14416
3D structure modelThis structure is from PDB ID 6cm4.
BioLiPBL0408379, BL0403379
Therapeutic Target DatabaseT67162
ChEMBLCHEMBL217
IUPHAR215
DrugBankBE0000756

Ligand

NameCHEMBL234641
Molecular formulaC23H23ClN2O
IUPAC nameN-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]naphthalene-1-carboxamide
Molecular weight378.9
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP5.2
SynonymsAKOS006597951
BDBM50203388
N-(1-(4-chlorobenzyl)piperidin-4-yl)-1-naphthamide
Inchi KeyAMSZGBUGZFGZJO-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H23ClN2O/c24-19-10-8-17(9-11-19)16-26-14-12-20(13-15-26)25-23(27)22-7-3-5-18-4-1-2-6-21(18)22/h1-11,20H,12-16H2,(H,25,27)
PubChem CID44431463
ChEMBLCHEMBL234641
IUPHARN/A
BindingDB50203388
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition0.0 %PMID17251022ChEMBL

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