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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide FF receptor 2
Species	Homo sapiens (Human)
Gene	NPFFR2
Synonym	NPFF2 receptor Neuropeptide G-protein coupled receptor GPR74 G-protein coupled receptor HLWAR77 G-protein coupled receptor 74 G protein-coupled receptor 74 F8Famide receptor NPGPR [ Show all ]
Disease	N/A
Length	522
Amino acid sequence	MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRRLGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWNVNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI
UniProt	Q9Y5X5
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5952
IUPHAR	301
DrugBank	N/A

Ligand

Name	CHEMBL3361420
Molecular formula	C23H32N6O2
IUPAC name	N-[[1-benzyl-4-(3-methoxyanilino)piperidin-4-yl]methyl]-2-(diaminomethylideneamino)acetamide
Molecular weight	424.549
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	1.7
Synonyms	BDBM50029119
Inchi Key	BODWLLWAGNGKQB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H32N6O2/c1-31-20-9-5-8-19(14-20)28-23(17-27-21(30)15-26-22(24)25)10-12-29(13-11-23)16-18-6-3-2-4-7-18/h2-9,14,28H,10-13,15-17H2,1H3,(H,27,30)(H4,24,25,26)
PubChem CID	118724981
ChEMBL	CHEMBL3361420
IUPHAR	N/A
BindingDB	50029119
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	884.0 nM	PMID25268943	BindingDB,ChEMBL

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