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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL3318835 |
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Molecular formula | C50H56Cl2F2N2O6 |
IUPAC name | bis[4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl] octanedioate |
Molecular weight | 889.903 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 0 |
XlogP | 10.2 |
Synonyms | BDBM50053380 |
Inchi Key | DPDUJCCKQWFBBQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C50H56Cl2F2N2O6/c51-41-19-15-39(16-20-41)49(27-33-55(34-28-49)31-5-7-45(57)37-11-23-43(53)24-12-37)61-47(59)9-3-1-2-4-10-48(60)62-50(40-17-21-42(52)22-18-40)29-35-56(36-30-50)32-6-8-46(58)38-13-25-44(54)26-14-38/h11-26H,1-10,27-36H2 |
PubChem CID | 118709163 |
ChEMBL | CHEMBL3318835 |
IUPHAR | N/A |
BindingDB | 50053380 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 2.5 nM | PMID25047579 | BindingDB,ChEMBL |
Ki | 2.9 nM | PMID25047579 | BindingDB,ChEMBL |
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