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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	W-84 dibromide
Molecular formula	C32H44Br2N4O4
IUPAC name	3-(1,3-dioxoisoindol-2-yl)propyl-[6-[3-(1,3-dioxoisoindol-2-yl)propyl-dimethylazaniumyl]hexyl]-dimethylazanium;dibromide
Molecular weight	708.536
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	None
Synonyms	Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium] dibromide SR-01000597956 AC1Q1R6J C-23460 J-013837 3-(1,3-dioxo-2-isoindolyl)propyl-[6-[3-(1,3-dioxo-2-isoindolyl)propyl-dimethylammonio]hexyl]-dimethylammonium dibromide DB-045480 N1,N6-bis(3-(1,3-dioxoisoindolin-2-yl)propyl)-N1,N1,N6,N6-tetramethylhexane-1,6-diaminium bromide A815135 Hexamethylene-bis-[dimethyl-(3-phthalimidopropyl)ammonium]dibromide SR-01000597956-1 1,6-Hexanediaminium, N,N'-bis(3-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propyl)-N,N,N',N'-tetramethyl-, dibromide AKOS024458552 MolPort-003-959-934 W-84 dibromide, >=98% (HPLC), solid 3-(1,3-dioxoisoindol-2-yl)propyl-[6-[3-(1,3-dioxoisoindol-2-yl)propyl-dimethylazaniumyl]hexyl]-dimethylazanium dibromide FT-0638093 SCHEMBL3989856 AC1L50XH Hexamethylenebis(dimethyl-(3-phthalimidopropyl)ammonium bromide) W 84 21093-51-6 B6338 CHEMBL266295 n,n'-bis[3-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)propyl]-n,n,n',n'-tetramethylhexane-1,6-diaminium dibromide 3-[1,3-bis(oxidanylidene)isoindol-2-yl]propyl-[6-[3-[1,3-bis(oxidanylidene)isoindol-2-yl]propyl-dimethyl-azaniumyl]hexyl]-dimethyl-azanium dibromide [ Show all ]
Inchi Key	DZRJZDQAGMZGGA-UHFFFAOYSA-L
Inchi ID	InChI=1S/C32H44N4O4.2BrH/c1-35(2,23-13-19-33-29(37)25-15-7-8-16-26(25)30(33)38)21-11-5-6-12-22-36(3,4)24-14-20-34-31(39)27-17-9-10-18-28(27)32(34)40;;/h7-10,15-18H,5-6,11-14,19-24H2,1-4H3;2*1H/q+2;;/p-2
PubChem CID	167961
ChEMBL	CHEMBL266295
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
pKA	4.37 -	PMID25051097	ChEMBL

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