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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

NameMLS000069104
Molecular formulaC17H17N3O3
IUPAC nameethyl 2-(2-methyl-7-oxo-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)acetate
Molecular weight311.341
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.8
Synonyms(2-Methyl-7-oxo-3-phenyl-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)-acetic acid ethyl ester
AKOS005628361
ethyl 2-(2-methyl-7-oxo-3-phenyl-1H-pyrazolo[1,5-a]pyrimidin-5-yl)acetate
SR-01000368046
CHEMBL1521564
[ Show all ]
Inchi KeyCKWZTVSSDLNIRW-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H17N3O3/c1-3-23-15(22)10-13-9-14(21)20-17(18-13)16(11(2)19-20)12-7-5-4-6-8-12/h4-9,19H,3,10H2,1-2H3
PubChem CID654182
ChEMBLN/A
IUPHARN/A
BindingDB37624
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5036800.0 nMN/ABindingDB
Ki24100.0 nMN/ABindingDB

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