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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL453001
Molecular formulaC17H22N6O
IUPAC nameN-ethyl-8-(6-methoxy-2-methylpyridin-3-yl)-N,2,7-trimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine
Molecular weight326.404
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.0
SynonymsBDBM29501
Pyrazolo[1,5-a]-1,3,5-triazine, 13-26
Inchi KeyCKXYYCLFMSXQGO-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H22N6O/c1-7-22(5)17-20-12(4)19-16-15(11(3)21-23(16)17)13-8-9-14(24-6)18-10(13)2/h8-9H,7H2,1-6H3
PubChem CID42618231
ChEMBLCHEMBL453001
IUPHARN/A
BindingDB29501
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5081.6 nMPMID19361209BindingDB,ChEMBL

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