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GPCR

NameProteinase-activated receptor 2
SpeciesHomo sapiens (Human)
GeneF2RL1
SynonymProtease-activated receptor-2
PAR2
PAR-2
GPR11
G-protein coupled receptor 11
[ Show all ]
DiseaseN/A
Length397
Amino acid sequenceMRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
UniProtP55085
Protein Data Bank5ndz, 5ndd
GPCR-HGmod modelP55085
3D structure modelThis structure is from PDB ID 5ndz.
BioLiPBL0377325, BL0377326
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5963
IUPHAR348
DrugBankN/A

Ligand

NameCHEMBL1689567
Molecular formulaC36H58N10O6
IUPAC name(2S,3S)-N-[2-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]-2-[[(2S)-2-[[2-(1H-indol-3-yl)acetyl]amino]-4-methylpentanoyl]amino]-3-methylpentanamide
Molecular weight726.924
Hydrogen bond acceptor7
Hydrogen bond donor9
XlogP2.0
SynonymsN/A
Inchi KeyFSOAHJSMZPPPED-NUCSNEOGSA-N
Inchi IDInChI=1S/C36H58N10O6/c1-7-22(6)31(46-34(51)28(16-21(4)5)44-29(47)17-23-18-41-25-12-9-8-11-24(23)25)35(52)42-19-30(48)43-26(13-10-14-40-36(38)39)33(50)45-27(32(37)49)15-20(2)3/h8-9,11-12,18,20-22,26-28,31,41H,7,10,13-17,19H2,1-6H3,(H2,37,49)(H,42,52)(H,43,48)(H,44,47)(H,45,50)(H,46,51)(H4,38,39,40)/t22-,26-,27-,28-,31-/m0/s1
PubChem CID51349580
ChEMBLCHEMBL1689567
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %PMID21294569ChEMBL

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