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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Mus musculus (Mouse)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	335
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProt	Q7TQP3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3358012
Molecular formula	C22H24F4N4O6S
IUPAC name	[3-(trifluoromethyl)oxetan-3-yl] (3R)-4-[5-[(2-fluoro-4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate
Molecular weight	548.51
Hydrogen bond acceptor	13
Hydrogen bond donor	0
XlogP	2.2
Synonyms	BDBM50103550 SCHEMBL1447912
Inchi Key	GHPSDAPCCXIXEV-CQSZACIVSA-N
Inchi ID	InChI=1S/C22H24F4N4O6S/c1-14-10-29(20(31)36-21(12-34-13-21)22(24,25)26)5-6-30(14)19-27-8-16(9-28-19)35-11-15-3-4-17(7-18(15)23)37(2,32)33/h3-4,7-9,14H,5-6,10-13H2,1-2H3/t14-/m1/s1
PubChem CID	58190324
ChEMBL	CHEMBL3358012
IUPHAR	N/A
BindingDB	50103550
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	80.0 nM	PMID25286150	BindingDB,ChEMBL
Intrinsic activity	100.0 %	PMID25286150	ChEMBL

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