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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3337859
Molecular formulaC43H48Br2N4O2
IUPAC name(1S,9R,15S,17R,18R,19S,20S,28R,35S,37R,38R,39S)-14,34-bis(prop-2-enyl)-10,29-dioxa-8,27-diaza-14,34-diazoniatridecacyclo[32.5.2.214,20.01,35.02,7.08,39.09,18.012,17.015,20.019,27.021,26.028,38.032,37]tritetraconta-2,4,6,11,21,23,25,31-octaene;dibromide
Molecular weight812.691
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogPNone
SynonymsN/A
Inchi KeyITPDHWYERZYIQU-QPFROQJOSA-L
Inchi IDInChI=1S/C43H48N4O2.2BrH/c1-3-16-46-18-14-42-31-10-6-8-12-33(31)45-38(42)36-28(21-34(42)46)26(23-46)13-20-48-40(36)44-32-11-7-5-9-30(32)43-15-19-47(17-4-2)24-27-25-49-41(45)37(39(43)44)29(27)22-35(43)47;;/h3-13,25,28-29,34-41H,1-2,14-24H2;2*1H/q+2;;/p-2/t28-,29-,34-,35-,36+,37+,38-,39-,40+,41+,42+,43+,46?,47?;;/m0../s1
PubChem CID118714968
ChEMBLCHEMBL3337859
IUPHARN/A
BindingDB50025035
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC5011.0 nMPMID25192059BindingDB,ChEMBL

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