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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesRattus norvegicus (Rat)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length468
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
UniProtQ7TQN8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5262
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3326666
Molecular formulaC20H22F4N4O6S
IUPAC name[(2S)-1,1,1-trifluoropropan-2-yl] 4-[5-fluoro-6-(2-methyl-6-methylsulfonylpyridin-3-yl)oxypyrimidin-4-yl]oxypiperidine-1-carboxylate
Molecular weight522.472
Hydrogen bond acceptor13
Hydrogen bond donor0
XlogP3.4
SynonymsBDBM50056003
Inchi KeyLDCKFNQAGLBTSF-LBPRGKRZSA-N
Inchi IDInChI=1S/C20H22F4N4O6S/c1-11-14(4-5-15(27-11)35(3,30)31)34-18-16(21)17(25-10-26-18)33-13-6-8-28(9-7-13)19(29)32-12(2)20(22,23)24/h4-5,10,12-13H,6-9H2,1-3H3/t12-/m0/s1
PubChem CID118711775
ChEMBLCHEMBL3326666
IUPHARN/A
BindingDB50056003
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50109.0 nMPMID25088191BindingDB,ChEMBL
Efficacy80.0 %PMID25088191ChEMBL

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