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GPCR

NameCorticotropin-releasing factor receptor 1
SpeciesRattus norvegicus (Rat)
GeneCrhr1
SynonymCRH-R1
CRH-R-1
CRFR1
CRFR-1
CRF1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
UniProtP35353
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4649
IUPHAR212
DrugBankN/A

Ligand

NameCHEMBL573284
Molecular formulaC18H21N5O2
IUPAC name4-[(1R)-1-cyclopropylethyl]-6-[(6-methoxy-2,5-dimethylpyridin-3-yl)amino]-5-oxopyrazine-2-carbonitrile
Molecular weight339.399
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.9
SynonymsBDBM50300141
(R)-4-(1-Cyclopropylethyl)-6-(6-methoxy-2,5-dimethylpyridin-3-ylamino)-5-oxo-4,5-dihydropyrazine-2-carbonitrile
Inchi KeyCLRRTXABLKAYGU-GFCCVEGCSA-N
Inchi IDInChI=1S/C18H21N5O2/c1-10-7-15(11(2)20-17(10)25-4)22-16-18(24)23(9-14(8-19)21-16)12(3)13-5-6-13/h7,9,12-13H,5-6H2,1-4H3,(H,21,22)/t12-/m1/s1
PubChem CID44596702
ChEMBLCHEMBL573284
IUPHARN/A
BindingDB50300141
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5010.0 nMPMID19954247BindingDB,ChEMBL

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