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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	G-protein coupled receptor 39
Species	Mus musculus (Mouse)
Gene	Gpr39
Synonym	GPR39
Disease	N/A for non-human GPCRs
Length	456
Amino acid sequence	MASSSGSNHICSRVIDHSHVPEFEVATWIKITLILVYLIIFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFKYKAVSGPRQVKLLIGFVWVTSALVALPLLFAMGIEYPLVNVPTHKGLNCNLSRTRHHDEPGNSNMSICTNLSNRWEVFQSSIFGAFAVYLVVLASVAFMCWNMMKVLMKSKQGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRTYFRAYMILLPFSDTFFYLSSVVNPLLYNVSSQQFRKVFWQVLCCRLTLQHANQEKRQRARFISTKDSTSSARSPLIFLASRRSNSSSRRTNKVFLSTFQTEAKPGEAKPQPLSPESPQTGSETKPAGSTTENSLQEQEV
UniProt	Q5U431
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3341584
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3342373
Molecular formula	C20H20ClN5
IUPAC name	4-N-[1-(4-chlorophenyl)cyclobutyl]-2-N-methyl-6-pyridin-2-ylpyrimidine-2,4-diamine
Molecular weight	365.865
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.3
Synonyms	BDBM50030780
Inchi Key	PLBKMJDLCJIFHY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H20ClN5/c1-22-19-24-17(16-5-2-3-12-23-16)13-18(25-19)26-20(10-4-11-20)14-6-8-15(21)9-7-14/h2-3,5-9,12-13H,4,10-11H2,1H3,(H2,22,24,25,26)
PubChem CID	118716414
ChEMBL	CHEMBL3342373
IUPHAR	N/A
BindingDB	50030780
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	34.0 nM	PMID25313322	BindingDB,ChEMBL

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