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GPCR

NameAlpha-1A adrenergic receptor
SpeciesRattus norvegicus (Rat)
GeneAdra1a
Synonymalpha1c
alpha1A-adrenoceptor
alpha1a
Alpha-1C adrenergic receptor
Alpha-1A adrenoreceptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProtP43140
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL319
IUPHAR22
DrugBankN/A

Ligand

NameFLUPHENAZINE
Molecular formulaC22H26F3N3OS
IUPAC name2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol
Molecular weight437.525
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP4.4
SynonymsKBio2_000769
API0006719
KBioGR_001375
BPBio1_000352
Lyogen (TN)
[ Show all ]
Inchi KeyPLDUPXSUYLZYBN-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
PubChem CID3372
ChEMBLCHEMBL726
IUPHAR204
BindingDB78433
DrugBankDB00623

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5024.0 nMDrugMatrix in vitro pharmacology dataChEMBL
Ki9.578 nMDrugMatrix in vitro pharmacology dataChEMBL

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