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GPCR

NameN-formyl peptide receptor 2
SpeciesHomo sapiens (Human)
GeneFPR2
SynonymFPRH1
FPRH2
FPRL1
HM63
Lipoxin A4 receptor
[ Show all ]
DiseaseN/A
Length351
Amino acid sequenceMETNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProtP25090
Protein Data BankN/A
GPCR-HGmod modelP25090
3D structure modelThis predicted structure model is from GPCR-EXP P25090.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4227
IUPHAR223
DrugBankN/A

Ligand

NameCHEMBL562380
Molecular formulaC21H20BrN3O3
IUPAC nameN-(4-bromophenyl)-2-[5-[(4-methoxyphenyl)methyl]-3-methyl-6-oxopyridazin-1-yl]acetamide
Molecular weight442.313
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.3
SynonymsBDBM50295523
N-(4-Bromophenyl)-2-[5-(4-methoxybenzyl)-3-methyl-6-oxo-6H-pyridazin-1-yl]-acetamide
Inchi KeyCMDXHAKUWAHYGG-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H20BrN3O3/c1-14-11-16(12-15-3-9-19(28-2)10-4-15)21(27)25(24-14)13-20(26)23-18-7-5-17(22)6-8-18/h3-11H,12-13H2,1-2H3,(H,23,26)
PubChem CID44233905
ChEMBLCHEMBL562380
IUPHARN/A
BindingDB50295523
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity70.0 %PMID19639995ChEMBL
EC50131.0 nMPMID19639995BindingDB
EC502400.0 nMPMID19639995BindingDB,ChEMBL
EC5013100.0 nMPMID19639995ChEMBL

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