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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	N-formyl peptide receptor 2
Species	Homo sapiens (Human)
Gene	FPR2
Synonym	FPRH1 FPRH2 FPRL1 HM63 Lipoxin A4 receptor LXA4 receptor LXA4R FPR2A FPR2/ALX Fpr-rs2 ALX ALX/FPR2 ALXR FMLP-R-I FMLP-related receptor I FMLPX formyl peptide receptor 2 formyl peptide receptor, related sequence 2 Formyl peptide receptor-like 1 RFP [ Show all ]
Disease	N/A
Length	351
Amino acid sequence	METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
UniProt	P25090
Protein Data Bank	N/A
GPCR-HGmod model	P25090
3D structure model	This predicted structure model is from GPCR-EXP P25090.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4227
IUPHAR	223
DrugBank	N/A

Ligand

Name	CHEMBL212113
Molecular formula	C20H21FN4O2
IUPAC name	1-(5-ethyl-1-methyl-3-oxo-2-phenylpyrazol-4-yl)-3-(3-fluoro-4-methylphenyl)urea
Molecular weight	368.412
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	3.7
Synonyms	BDBM50186945 1-(3-ethyl-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)-3-(3-fluoro-4-methylphenyl)urea
Inchi Key	CMJJSFWJYMUEIL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H21FN4O2/c1-4-17-18(19(26)25(24(17)3)15-8-6-5-7-9-15)23-20(27)22-14-11-10-13(2)16(21)12-14/h5-12H,4H2,1-3H3,(H2,22,23,27)
PubChem CID	44413547
ChEMBL	CHEMBL212113
IUPHAR	N/A
BindingDB	50186945
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	310.0 nM	PMID16697190	BindingDB,ChEMBL

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