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Name | 5-hydroxytryptamine receptor 5A |
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Species | Homo sapiens (Human) |
Gene | HTR5A |
Synonym | 5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A [ Show all ] |
Disease | N/A |
Length | 357 |
Amino acid sequence | MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH |
UniProt | P47898 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47898 |
3D structure model | This predicted structure model is from GPCR-EXP P47898. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3426 |
IUPHAR | 10 |
DrugBank | BE0004688 |
Name | CHEMBL3654206 |
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Molecular formula | C19H17F3N4O |
IUPAC name | N-(diaminomethylidene)-8-(2,6-difluorophenyl)-5-fluorospiro[1,3-dihydroisoquinoline-4,1'-cyclopropane]-2-carboxamide |
Molecular weight | 374.367 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 2.9 |
Synonyms | US8962612, 66 BDBM148163 SCHEMBL16518312 |
Inchi Key | CMKAVZVNVJNXJG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C19H17F3N4O/c20-12-2-1-3-13(21)15(12)10-4-5-14(22)16-11(10)8-26(9-19(16)6-7-19)18(27)25-17(23)24/h1-5H,6-9H2,(H4,23,24,25,27) |
PubChem CID | 60151043 |
ChEMBL | CHEMBL3654206 |
IUPHAR | N/A |
BindingDB | 148163 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.75 nM | , None | BindingDB,ChEMBL |
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