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GPCR

NameOrexin receptor type 2
SpeciesRattus norvegicus (Rat)
GeneHcrtr2
Synonymhypocretin receptor 2
Hypocretin receptor type 2
hypocretin (orexin) receptor 2
orexin receptor type 2
Ox-2-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
UniProtP56719
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1275216
IUPHAR322
DrugBankN/A

Ligand

NameSCHEMBL9977884
Molecular formulaC21H20FN7O
IUPAC nameN-ethyl-N-[2-[3-(5-fluoropyridin-2-yl)pyrazol-1-yl]ethyl]-2-(triazol-2-yl)benzamide
Molecular weight405.437
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP2.4
SynonymsCHEMBL3398482
Inchi KeyWNLPXECFJHLAQT-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H20FN7O/c1-2-27(21(30)17-5-3-4-6-20(17)29-24-10-11-25-29)13-14-28-12-9-19(26-28)18-8-7-16(22)15-23-18/h3-12,15H,2,13-14H2,1H3
PubChem CID57389637
ChEMBLCHEMBL3398482
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Kb6.06 nMPMID25693785ChEMBL

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